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Literature DB >> 29728399

Defining success with cellular therapeutics: the current landscape for clinical end point and toxicity analysis.

Abstract

Cellular therapies play a major and expanding role in the treatment of hematologic diseases. For each of these therapies, a narrow therapeutic window exists, where efficacy is maximized and toxicities minimized. This review focuses on one of the most established cellular therapies, hematopoietic stem cell transplant, and one of the newest cellular therapies, chimeric antigen receptor-T cells. In this review, I will discuss the current state of the field for clinical end point analysis with each of these therapeutics, including their critical toxicities, and focus on the major elements of success for each of these complex treatments for hematologic disease.

Entities: Chemical

Mesh：

Year: 2018 PMID： 29728399 PMCID： PMC6032897 DOI： 10.1182/blood-2018-02-785881

Source DB: PubMed Journal: Blood ISSN： 0006-4971 Impact factor: 25.476

177 in total

1. CCL25 increases thymopoiesis after androgen withdrawal.

Authors: Kirsten M Williams; Philip J Lucas; Catherine V Bare; Jiun Wang; Yu-Waye Chu; Ezekiel Tayler; Veena Kapoor; Ronald E Gress
Journal: Blood Date: 2008-08-11 Impact factor: 22.113

2. Inducible caspase-9 suicide gene controls adverse effects from alloreplete T cells after haploidentical stem cell transplantation.

Authors: Xiaoou Zhou; Gianpietro Dotti; Robert A Krance; Caridad A Martinez; Swati Naik; Rammurti T Kamble; April G Durett; Olga Dakhova; Barbara Savoldo; Antonio Di Stasi; David M Spencer; Yu-Feng Lin; Hao Liu; Bambi J Grilley; Adrian P Gee; Cliona M Rooney; Helen E Heslop; Malcolm K Brenner
Journal: Blood Date: 2015-05-14 Impact factor: 22.113

3. Immunotherapy of non-Hodgkin's lymphoma with a defined ratio of CD8+ and CD4+ CD19-specific chimeric antigen receptor-modified T cells.

Authors: Cameron J Turtle; Laïla-Aïcha Hanafi; Carolina Berger; Michael Hudecek; Barbara Pender; Emily Robinson; Reed Hawkins; Colette Chaney; Sindhu Cherian; Xueyan Chen; Lorinda Soma; Brent Wood; Daniel Li; Shelly Heimfeld; Stanley R Riddell; David G Maloney
Journal: Sci Transl Med Date: 2016-09-07 Impact factor: 17.956

4. Bone marrow transplantation for chronic myelogenous leukemia in chronic phase. Increased risk for relapse associated with T-cell depletion.

Authors: J M Goldman; R P Gale; M M Horowitz; J C Biggs; R E Champlin; E Gluckman; R G Hoffmann; S J Jacobsen; A M Marmont; P B McGlave
Journal: Ann Intern Med Date: 1988-06 Impact factor: 25.391

5. Th17 plasticity and transition toward a pathogenic cytokine signature are regulated by cyclosporine after allogeneic SCT.

Authors: Kate H Gartlan; Antiopi Varelias; Motoko Koyama; Renee J Robb; Kate A Markey; Karshing Chang; Andrew N Wilkinson; David Smith; Md Ashik Ullah; Rachel D Kuns; Neil C Raffelt; Stuart D Olver; Katie E Lineburg; Bianca E Teal; Melody Cheong; Michele W L Teng; Mark J Smyth; Siok-Keen Tey; Kelli P A MacDonald; Geoffrey R Hill
Journal: Blood Adv Date: 2017-01-26

6. Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19.

Authors: James N Kochenderfer; Wyndham H Wilson; John E Janik; Mark E Dudley; Maryalice Stetler-Stevenson; Steven A Feldman; Irina Maric; Mark Raffeld; Debbie-Ann N Nathan; Brock J Lanier; Richard A Morgan; Steven A Rosenberg
Journal: Blood Date: 2010-07-28 Impact factor: 22.113

7. An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD.

Authors: Jonathan C Poe; Wei Jia; Hsuan Su; Sarah Anand; Jeremy J Rose; Prasanthi V Tata; Amy N Suthers; Corbin D Jones; Pei Fen Kuan; Benjamin G Vincent; Jonathan S Serody; Mitchell E Horwitz; Vincent T Ho; Steven Z Pavletic; Frances T Hakim; Kouros Owzar; Dadong Zhang; Bruce R Blazar; Christian W Siebel; Nelson J Chao; Ivan Maillard; Stefanie Sarantopoulos
Journal: Blood Date: 2017-08-29 Impact factor: 22.113

8. Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality.

Authors: Asim Saha; Roddy S O'Connor; Govindarajan Thangavelu; Scott B Lovitch; Durga Bhavani Dandamudi; Caleph B Wilson; Benjamin G Vincent; Victor Tkachev; Jan M Pawlicki; Scott N Furlan; Leslie S Kean; Kazutoshi Aoyama; Patricia A Taylor; Angela Panoskaltsis-Mortari; Rocio Foncea; Parvathi Ranganathan; Steven M Devine; Joel S Burrill; Lili Guo; Catarina Sacristan; Nathaniel W Snyder; Ian A Blair; Michael C Milone; Michael L Dustin; James L Riley; David A Bernlohr; William J Murphy; Brian T Fife; David H Munn; Jeffrey S Miller; Jonathan S Serody; Gordon J Freeman; Arlene H Sharpe; Laurence A Turka; Bruce R Blazar
Journal: J Clin Invest Date: 2016-06-13 Impact factor: 14.808

9. Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention.

Authors: Scott N Furlan; Benjamin Watkins; Victor Tkachev; Ryan Flynn; Sarah Cooley; Swetha Ramakrishnan; Karnail Singh; Cindy Giver; Kelly Hamby; Linda Stempora; Aneesah Garrett; Jingyang Chen; Kayla M Betz; Carly G K Ziegler; Gregory K Tharp; Steven E Bosinger; Daniel E L Promislow; Jeffrey S Miller; Edmund K Waller; Bruce R Blazar; Leslie S Kean
Journal: Sci Transl Med Date: 2015-11-25 Impact factor: 17.956

10. Central memory CD8+ T cells induce graft-versus-host disease and mediate graft-versus-leukemia.

Authors: Hong Zheng; Catherine Matte-Martone; Dhanpat Jain; Jennifer McNiff; Warren D Shlomchik
Journal: J Immunol Date: 2009-05-15 Impact factor: 5.422

3 in total

Review 1. Patient-Reported Outcomes with Chimeric Antigen Receptor T Cell Therapy: Challenges and Opportunities.

Authors: Rajshekhar Chakraborty; Surbhi Sidana; Gunjan L Shah; Michael Scordo; Betty K Hamilton; Navneet S Majhail
Journal: Biol Blood Marrow Transplant Date: 2018-11-28 Impact factor: 5.742

2. Intracellular and Extracellular Antifreeze Protein Significantly Improves Mammalian Cell Cryopreservation.

Authors: Jonathan A Sreter; Thomas L Foxall; Krisztina Varga
Journal: Biomolecules Date: 2022-05-05

3. CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease.

Authors: Emmanouela Tsagkaraki; Sarah M Nicoloro; Tiffany DeSouza; Javier Solivan-Rivera; Anand Desai; Lawrence M Lifshitz; Yuefei Shen; Mark Kelly; Adilson Guilherme; Felipe Henriques; Nadia Amrani; Raed Ibraheim; Tomas C Rodriguez; Kevin Luk; Stacy Maitland; Randall H Friedline; Lauren Tauer; Xiaodi Hu; Jason K Kim; Scot A Wolfe; Erik J Sontheimer; Silvia Corvera; Michael P Czech
Journal: Nat Commun Date: 2021-11-26 Impact factor: 17.694

3 in total