Literature DB >> 29727672

HippoCA3mpal Stem Cell Models Expose Dysfunctional Circuits in Schizophrenia.

Mandy Johnstone1, Rana Fetit2.   

Abstract

In this issue of Cell Stem Cell, Sarkar et al. (2018) describe an efficient method for the generation of human hippocampal pyramidal neurons from stem cells. They developed a compelling in vitro model that recapitulates synaptic connectivity within the hippocampus and showed that cells derived from patients with schizophrenia exhibit abnormal electrical activity.
Copyright © 2018 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 29727672      PMCID： PMC6192513          DOI： 10.1016/j.stem.2018.04.008

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   24.633


  10 in total

1.  Modelling schizophrenia using human induced pluripotent stem cells.

Authors:  Kristen J Brennand; Anthony Simone; Jessica Jou; Chelsea Gelboin-Burkhart; Ngoc Tran; Sarah Sangar; Yan Li; Yangling Mu; Gong Chen; Diana Yu; Shane McCarthy; Jonathan Sebat; Fred H Gage
Journal:  Nature       Date:  2011-04-13       Impact factor: 49.962

2.  Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity.

Authors:  Ki-Jun Yoon; Ha Nam Nguyen; Gianluca Ursini; Fengyu Zhang; Nam-Shik Kim; Zhexing Wen; Georgia Makri; David Nauen; Joo Heon Shin; Youngbin Park; Raeeun Chung; Eva Pekle; Ce Zhang; Maxwell Towe; Syed Mohammed Qasim Hussaini; Yohan Lee; Dan Rujescu; David St Clair; Joel E Kleinman; Thomas M Hyde; Gregory Krauss; Kimberly M Christian; Judith L Rapoport; Daniel R Weinberger; Hongjun Song; Guo-Li Ming
Journal:  Cell Stem Cell       Date:  2014-07-03       Impact factor: 24.633

3.  Synaptic proteins in the hippocampus indicative of increased neuronal activity in CA3 in schizophrenia.

Authors:  Wei Li; Subroto Ghose; Kelly Gleason; Anita Begovic; Jessica Perez; John Bartko; Scott Russo; Anthony D Wagner; Lynn Selemon; Carol A Tamminga
Journal:  Am J Psychiatry       Date:  2015-01-13       Impact factor: 18.112

4.  Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study.

Authors:  M D Nelson; A J Saykin; L A Flashman; H J Riordan
Journal:  Arch Gen Psychiatry       Date:  1998-05

5.  Synaptic dysregulation in a human iPS cell model of mental disorders.

Authors:  Zhexing Wen; Ha Nam Nguyen; Ziyuan Guo; Matthew A Lalli; Xinyuan Wang; Yijing Su; Nam-Shik Kim; Ki-Jun Yoon; Jaehoon Shin; Ce Zhang; Georgia Makri; David Nauen; Huimei Yu; Elmer Guzman; Cheng-Hsuan Chiang; Nadine Yoritomo; Kozo Kaibuchi; Jizhong Zou; Kimberly M Christian; Linzhao Cheng; Christopher A Ross; Russell L Margolis; Gong Chen; Kenneth S Kosik; Hongjun Song; Guo-li Ming
Journal:  Nature       Date:  2014-08-17       Impact factor: 49.962

Review 6.  Specification of neuronal and glial subtypes from human pluripotent stem cells.

Authors:  Huisheng Liu; Su-Chun Zhang
Journal:  Cell Mol Life Sci       Date:  2011-07-24       Impact factor: 9.261

7.  Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro.

Authors:  Anindita Sarkar; Arianna Mei; Apua C M Paquola; Shani Stern; Cedric Bardy; Jason R Klug; Stacy Kim; Neda Neshat; Hyung Joon Kim; Manching Ku; Maxim N Shokhirev; David H Adamowicz; Maria C Marchetto; Roberto Jappelli; Jennifer A Erwin; Krishnan Padmanabhan; Matthew Shtrahman; Xin Jin; Fred H Gage
Journal:  Cell Stem Cell       Date:  2018-05-03       Impact factor: 24.633

8.  Decreased numerical density of CA3 hippocampal mossy fiber synapses in schizophrenia.

Authors:  Natalya S Kolomeets; Diana D Orlovskaya; Natalya A Uranova
Journal:  Synapse       Date:  2007-08       Impact factor: 2.562

9.  Modeling hippocampal neurogenesis using human pluripotent stem cells.

Authors:  Diana Xuan Yu; Francesco Paolo Di Giorgio; Jun Yao; Maria Carolina Marchetto; Kristen Brennand; Rebecca Wright; Arianna Mei; Lauren McHenry; David Lisuk; Jaeson Michael Grasmick; Pedro Silberman; Giovanna Silberman; Roberto Jappelli; Fred H Gage
Journal:  Stem Cell Reports       Date:  2014-02-27       Impact factor: 7.765

10.  Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia.

Authors:  K Brennand; J N Savas; Y Kim; N Tran; A Simone; K Hashimoto-Torii; K G Beaumont; H J Kim; A Topol; I Ladran; M Abdelrahim; B Matikainen-Ankney; S-h Chao; M Mrksich; P Rakic; G Fang; B Zhang; J R Yates; F H Gage
Journal:  Mol Psychiatry       Date:  2014-04-01       Impact factor: 15.992
  10 in total
  1 in total

Review 1.  Modeling Psychiatric Disorder Biology with Stem Cells.

Authors:  Debamitra Das; Kyra Feuer; Marah Wahbeh; Dimitrios Avramopoulos
Journal:  Curr Psychiatry Rep       Date:  2020-04-21       Impact factor: 5.285
  1 in total

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