Literature DB >> 2972736

In vitro inhibition of human herpesvirus-6 by phosphonoformate.

H Z Streicher1, C L Hung, D V Ablashi, K Hellman, C Saxinger, J Fullen, S Z Salahuddin.   

Abstract

HSB-2 cell cultures productively infected with human herpesvirus-6 were treated with the antiviral drugs phosphonoformic acid (PFA), acyclovir (ACV), and gancyclovir (DHPG). ACV and DHPG showed significant toxic effects on uninfected HSB-2 cells, yet only incompletely inhibited viral expression upon infection of the cells. PFA, however, showed little direct toxicity on HSB-2 cells while viral replication was inhibited significantly.

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Year:  1988        PMID： 2972736     DOI： 10.1016/0166-0934(88)90075-4

Source DB:  PubMed          Journal:  J Virol Methods        ISSN： 0166-0934            Impact factor:   2.014


  4 in total

Review 1.  Human herpesvirus 6.

Authors:  D K Braun; G Dominguez; P E Pellett
Journal:  Clin Microbiol Rev       Date:  1997-07       Impact factor: 26.132

2.  Effect of primary Epstein-Barr virus infection on human herpesvirus 6, cytomegalovirus, and measles virus immunoglobulin G titers.

Authors:  A Linde; E Fridell; H Dahl; J Andersson; P Biberfeld; B Wahren
Journal:  J Clin Microbiol       Date:  1990-02       Impact factor: 5.948

3.  Quantitative PCR for human herpesviruses 6 and 7.

Authors:  P Secchiero; D Zella; R W Crowley; R C Gallo; P Lusso
Journal:  J Clin Microbiol       Date:  1995-08       Impact factor: 5.948

4.  Inhibition of human herpesvirus 6 replication by 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (2HM-HBG) and other antiviral compounds.

Authors:  A Akesson-Johansson; J Harmenberg; B Wahren; A Linde
Journal:  Antimicrob Agents Chemother       Date:  1990-12       Impact factor: 5.191
  4 in total

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