Literature DB >> 29727194

Metformin Therapy for Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction versus Pulmonary Arterial Hypertension.

Dmitry A Goncharov1, Elena A Goncharova1, Stevan P Tofovic1, Jian Hu1, Jeff J Baust1, Andressa Z Pena1, Arnab Ray1, Analise Rode1, Rebecca R Vanderpool2, Ana L Mora1, Mark T Gladwin1, Yen-Chun Lai1.   

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Year:  2018        PMID： 29727194      PMCID： PMC6118018          DOI： 10.1164/rccm.201801-0022LE

Source DB:  PubMed          Journal:  Am J Respir Crit Care Med        ISSN： 1073-449X            Impact factor:   21.405


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  12 in total

Review 1.  Combined post- and pre-capillary pulmonary hypertension in heart failure with preserved ejection fraction.

Authors:  Debra D Dixon; Amar Trivedi; Sanjiv J Shah
Journal:  Heart Fail Rev       Date:  2016-05       Impact factor: 4.214

2.  Gender-related different effects of a combined therapy of Exenatide and Metformin on overweight or obesity patients with type 2 diabetes mellitus.

Authors:  Huibiao Quan; Huachuan Zhang; Weiping Wei; Tuanyu Fang
Journal:  J Diabetes Complications       Date:  2016-01-15       Impact factor: 2.852

3.  Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation.

Authors:  Brian S Zuckerbraun; Sruti Shiva; Emeka Ifedigbo; Michael A Mathier; Kevin P Mollen; Jayashree Rao; Philip M Bauer; Justin J W Choi; Erin Curtis; Augustine M K Choi; Mark T Gladwin
Journal:  Circulation       Date:  2009-12-21       Impact factor: 29.690

Review 4.  Pulmonary arterial hypertension-related myopathy: an overview of current data and future perspectives.

Authors:  A M Marra; M Arcopinto; E Bossone; N Ehlken; A Cittadini; E Grünig
Journal:  Nutr Metab Cardiovasc Dis       Date:  2014-10-19       Impact factor: 4.222

5.  Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle.

Authors:  Orsolya M Palacios; Juan J Carmona; Shaday Michan; Ke Yun Chen; Yasuko Manabe; Jack Lee Ward; Laurie J Goodyear; Qiang Tong
Journal:  Aging (Albany NY)       Date:  2009-08-15       Impact factor: 5.682

6.  Protective role of the antidiabetic drug metformin against chronic experimental pulmonary hypertension.

Authors:  C Agard; M Rolli-Derkinderen; E Dumas-de-La-Roque; M Rio; C Sagan; J P Savineau; G Loirand; P Pacaud
Journal:  Br J Pharmacol       Date:  2009-10-08       Impact factor: 8.739

7.  Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.

Authors:  Roxane Paulin; Peter Dromparis; Gopinath Sutendra; Vikram Gurtu; Sotirios Zervopoulos; Lyndsay Bowers; Alois Haromy; Linda Webster; Steeve Provencher; Sebastien Bonnet; Evangelos D Michelakis
Journal:  Cell Metab       Date:  2014-10-02       Impact factor: 27.287

8.  SIRT3-AMP-Activated Protein Kinase Activation by Nitrite and Metformin Improves Hyperglycemia and Normalizes Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction.

Authors:  Yen-Chun Lai; Diana M Tabima; John J Dube; Kara S Hughan; Rebecca R Vanderpool; Dmitry A Goncharov; Claudette M St Croix; Adolfo Garcia-Ocaña; Elena A Goncharova; Stevan P Tofovic; Ana L Mora; Mark T Gladwin
Journal:  Circulation       Date:  2016-01-26       Impact factor: 29.690

9.  Gender differences in metformin effect on aging, life span and spontaneous tumorigenesis in 129/Sv mice.

Authors:  Vladimir N Anisimov; Tatiana S Piskunova; Irina G Popovich; Mark A Zabezhinski; Margarita L Tyndyk; Peter A Egormin; Maria V Yurova; Svetlana V Rosenfeld; Anna V Semenchenko; Irina G Kovalenko; Tatiana E Poroshina; Lev M Berstein
Journal:  Aging (Albany NY)       Date:  2010-12       Impact factor: 5.682

10.  Metformin Reverses Development of Pulmonary Hypertension via Aromatase Inhibition.

Authors:  Afshan Dean; Margaret Nilsen; Lynn Loughlin; Ian P Salt; Margaret R MacLean
Journal:  Hypertension       Date:  2016-06-13       Impact factor: 10.190
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  12 in total

1.  Exploring New Therapeutic Pathways in Pulmonary Hypertension. Metabolism, Proliferation, and Personalized Medicine.

Authors:  M Patricia George; Mark T Gladwin; Brian B Graham
Journal:  Am J Respir Cell Mol Biol       Date:  2020-09       Impact factor: 6.914

Review 2.  The Search for Disease-Modifying Therapies in Pulmonary Hypertension.

Authors:  Chen-Shan Chen Woodcock; Stephen Y Chan
Journal:  J Cardiovasc Pharmacol Ther       Date:  2019-02-17       Impact factor: 2.457

Review 3.  Endothelial Senescence: A New Age in Pulmonary Hypertension.

Authors:  Miranda K Culley; Stephen Y Chan
Journal:  Circ Res       Date:  2022-03-17       Impact factor: 17.367

Review 4.  Metabolic syndrome, neurohumoral modulation, and pulmonary arterial hypertension.

Authors:  Bradley A Maron; Jane A Leopold; Anna R Hemnes
Journal:  Br J Pharmacol       Date:  2020-02-18       Impact factor: 8.739

Review 5.  Lessons from Cancer Metabolism for Pulmonary Arterial Hypertension and Fibrosis.

Authors:  SeungHye Han; Navdeep S Chandel
Journal:  Am J Respir Cell Mol Biol       Date:  2021-08       Impact factor: 6.914

Review 6.  Pathological Mechanisms and Potential Therapeutic Targets of Pulmonary Arterial Hypertension: A Review.

Authors:  Ying Xiao; Pei-Pei Chen; Rui-Lin Zhou; Yang Zhang; Zhuang Tian; Shu-Yang Zhang
Journal:  Aging Dis       Date:  2020-12-01       Impact factor: 6.745

7.  Mechanistic Phase II Clinical Trial of Metformin in Pulmonary Arterial Hypertension.

Authors:  Evan L Brittain; Kevin Niswender; Vineet Agrawal; Xinping Chen; Run Fan; Meredith E Pugh; Todd W Rice; Ivan M Robbins; Haocan Song; Christopher Thompson; Fei Ye; Chang Yu; He Zhu; James West; John H Newman; Anna R Hemnes
Journal:  J Am Heart Assoc       Date:  2020-11-10       Impact factor: 5.501

Review 8.  Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms.

Authors:  Sheng Chen; Donghao Gan; Sixiong Lin; Yiming Zhong; Mingjue Chen; Xuenong Zou; Zengwu Shao; Guozhi Xiao
Journal:  Theranostics       Date:  2022-03-06       Impact factor: 11.600

Review 9.  AMPK and the Need to Breathe and Feed: What's the Matter with Oxygen?

Authors:  A Mark Evans; D Grahame Hardie
Journal:  Int J Mol Sci       Date:  2020-05-15       Impact factor: 6.208

Review 10.  Metformin in Pulmonary Hypertension in Left Heart Disease.

Authors:  Vinaya Mulkareddy; Marc A Simon
Journal:  Front Med (Lausanne)       Date:  2020-08-19
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