Testing homogeneity in semiparametric mixture case-control models.

Parametric and semiparametric mixture models have been widely used in applications from many areas, and it is often of interest to test homogeneity in these models. However, hypothesis testing is nonstandard due to the fact that several regularity conditions do not hold under the null hypothesis. We consider a semiparametric mixture case-control model, in the sense that the density ratio of two distributions is assumed to be of an exponential form, while the baseline density is unspecified. This model was first considered by Qin and Liang (2011, biometrics), and they proposed a modified score statistic for testing homogeneity. In this paper, we consider alternative testing procedures based on supremum statistics, which could improve power against certain types of alternatives. We demonstrate the connection and comparison among proposed and existing these approaches. In addition, we provide a unified theoretical justification of the supremum test and other existing test statistics from an empirical likelihood perspective. The finite sample performance of the supremum test statistics were evaluated in simulation studies.