Mélodie Bourdages1, Marie-Élaine Demers1, Samuel Dubé1, Cédric Gasse1, Mario Girard2, Amélie Boutin2, Joel G Ray3, Emmanuel Bujold4, Suzanne Demers5. 1. Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, Québec City, QC. 2. CHU de Québec-Université Laval Research Center, Québec City, QC. 3. Department of Obstetrics and Gynecology, St Michael's Hospital, University of Toronto, Toronto, ON. 4. Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, Québec City, QC; CHU de Québec-Université Laval Research Center, Québec City, QC. 5. Department of Obstetrics and Gynecology, Faculty of Medicine, Université Laval, Québec City, QC; CHU de Québec-Université Laval Research Center, Québec City, QC. Electronic address: suzanne.demers@crchudequebec.ulaval.ca.
Abstract
OBJECTIVE: To estimate the discriminative capacity of first-trimester subcutaneous (SATT), visceral (VATT), and total (TATT) adipose tissue thickness in predicting gestational diabetes mellitus (GDM), including that requiring insulin. METHODS: We prospectively recruited a cohort of 1048 nulliparous women. Ultrasound images were used to determine abdominal SATT, VATT, and TATT at 11 to 14 weeks' gestation. Multivariate logistic regression models were used to predict GDM, as well as insulin-requiring GDM. Model discrimination was expressed as area under the curve (AUC). RESULTS: SATT (AUC 0.66, 95% CI 0.59-0.73), VATT (AUC 0.65, 95% CI 0.58-0.73), and TATT (AUC 0.68, 95% CI 0.61-0.76) were each associated with subsequent GDM. The respective AUC values for insulin-requiring GDM were 0.70 (95% CI 0.61-0.79), 0.73 (95% CI 0.65-0.82), and 0.76 (95% CI 0.67-0.84). At a false-positive rate of 10%, the detection rate for insulin-requiring GDM was 19% for maternal age ≥35 years, 31% for a BMI ≥31.6 kg/m2, and 31% for TATT ≥61 mm, increasing to 42% in the model comprising all three measures. CONCLUSION: First-trimester ultrasound measurement of adipose tissue is associated with a higher chance of developing GDM, especially insulin-requiring GDM.
OBJECTIVE: To estimate the discriminative capacity of first-trimester subcutaneous (SATT), visceral (VATT), and total (TATT) adipose tissue thickness in predicting gestational diabetes mellitus (GDM), including that requiring insulin. METHODS: We prospectively recruited a cohort of 1048 nulliparous women. Ultrasound images were used to determine abdominal SATT, VATT, and TATT at 11 to 14 weeks' gestation. Multivariate logistic regression models were used to predict GDM, as well as insulin-requiring GDM. Model discrimination was expressed as area under the curve (AUC). RESULTS:SATT (AUC 0.66, 95% CI 0.59-0.73), VATT (AUC 0.65, 95% CI 0.58-0.73), and TATT (AUC 0.68, 95% CI 0.61-0.76) were each associated with subsequent GDM. The respective AUC values for insulin-requiring GDM were 0.70 (95% CI 0.61-0.79), 0.73 (95% CI 0.65-0.82), and 0.76 (95% CI 0.67-0.84). At a false-positive rate of 10%, the detection rate for insulin-requiring GDM was 19% for maternal age ≥35 years, 31% for a BMI ≥31.6 kg/m2, and 31% for TATT ≥61 mm, increasing to 42% in the model comprising all three measures. CONCLUSION: First-trimester ultrasound measurement of adipose tissue is associated with a higher chance of developing GDM, especially insulin-requiring GDM.
Authors: João Guilherme Alves; Alex Sandro Rolland Souza; José Natal Figueiroa; Carla Adriane Leal de Araújo; Angélica Guimarães; Joel Geoffrey Ray Journal: Sci Rep Date: 2020-02-06 Impact factor: 4.379
Authors: Alexandra Cremona; Kevin Hayes; Clodagh S O'Gorman; Ciara Ní Laighin; Khadijah I Ismail; Alan E Donnelly; Jill Hamilton; Amanda Cotter Journal: BMC Med Imaging Date: 2019-12-17 Impact factor: 1.930