Jennifer M Burke1, Warren Jackson2, Alyn H Morice3. 1. GI Physiology, Hull and East Yorkshire Hospitals NHS Trust, Castle Hill Hospital, Hull HU16 5JQ, United Kingdom. Electronic address: Jennifer.burke@hey.nhs.uk. 2. GI Physiology, Hull and East Yorkshire Hospitals NHS Trust, Castle Hill Hospital, Hull HU16 5JQ, United Kingdom. Electronic address: Warren.Jackson@hey.nhs.uk. 3. Hull York Medical School, Castle Hill Hospital, Hull, HU16 5JQ, United Kingdom. Electronic address: a.h.morice@hull.ac.uk.
Abstract
PURPOSE: Cough Hypersensitivity Syndrome is the urge to cough following minimal stimulation, but its mechanism and method of provocation remain unexplained. 121 patients (44 males, 77 females; age range 18-81 years) were evaluated. PROCEDURES: High resolution manometry was performed on consecutive patients presenting with unexplained respiratory symptoms (Respiratory Group 61). Data were compared with matched controls, i.e. dyspepsia without respiratory symptoms (Dyspepsia Group 60). MAIN FINDINGS: Results showed increased inspiratory gastro-oesophageal pressure gradient due to significantly lower intra-oesophageal pressure on inspiration (p = 0.001), and reduced oesophageal motility in the Respiratory Group. CONCLUSIONS: Further research in respiratory conditions characterised by decreased intrathoracic pressure during inspiration is needed.
PURPOSE: Cough Hypersensitivity Syndrome is the urge to cough following minimal stimulation, but its mechanism and method of provocation remain unexplained. 121 patients (44 males, 77 females; age range 18-81 years) were evaluated. PROCEDURES: High resolution manometry was performed on consecutive patients presenting with unexplained respiratory symptoms (Respiratory Group 61). Data were compared with matched controls, i.e. dyspepsia without respiratory symptoms (Dyspepsia Group 60). MAIN FINDINGS: Results showed increased inspiratory gastro-oesophageal pressure gradient due to significantly lower intra-oesophageal pressure on inspiration (p = 0.001), and reduced oesophageal motility in the Respiratory Group. CONCLUSIONS: Further research in respiratory conditions characterised by decreased intrathoracic pressure during inspiration is needed.
Authors: Alyn H Morice; Eva Millqvist; Kristina Bieksiene; Surinder S Birring; Peter Dicpinigaitis; Christian Domingo Ribas; Michele Hilton Boon; Ahmad Kantar; Kefang Lai; Lorcan McGarvey; David Rigau; Imran Satia; Jacky Smith; Woo-Jung Song; Thomy Tonia; Jan W K van den Berg; Mirjam J G van Manen; Angela Zacharasiewicz Journal: Eur Respir J Date: 2020-01-02 Impact factor: 16.671