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Literature DB >> 2972304

Thrombin and plasmin activity in coronary artery disease.

M Small¹, G D Lowe, J T Douglas, I Hutton, A R Lorimer, C D Forbes.

Abstract

Basal plasmin and thrombin activity in plasma were assessed by radioimmunoassay of the fibrinogen derivatives containing the sequence B beta 15-42 and of fibrinopeptide A respectively in a cross sectional controlled study of men with coronary artery disease. Compared with healthy controls (n = 33) men with angiographically defined coronary artery disease (n = 98) had a modest but significant increase in concentrations of fibrinopeptide A, indicating an activated coagulation system. Concentrations of B beta 15-42 were similar in those with coronary artery disease and in the controls. The enhanced thrombin activity in coronary artery disease is in keeping with current evidence suggesting an association between coronary artery disease and a hypercoagulable state.

Entities: Disease Gene Species

Mesh：

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Year: 1988 PMID： 2972304 PMCID： PMC1216554 DOI： 10.1136/hrt.60.3.201

Source DB: PubMed Journal: Br Heart J ISSN： 0007-0769

21 in total

1. Plasma beta-thromboglobulin, fibrinopeptide A and B beta 15-42 antigen in relation to postoperative DVT, malignancy and stanozolol treatment.

Authors: J T Douglas; S L Blamey; G D Lowe; D C Carter; C D Forbes
Journal: Thromb Haemost Date: 1985-04-22 Impact factor: 5.249

2. ABC of nutrition. Obesity: diagnosis and risks.

Authors: A S Truswell
Journal: Br Med J (Clin Res Ed) Date: 1985-09-07

3. Haemostatic variables and the outcome of myocardial infarction.

Authors: A P Haines; D Howarth; W R North; E Goldenberg; Y Stirling; T W Meade; E B Raftery; M W Millar Craig
Journal: Thromb Haemost Date: 1983-12-30 Impact factor: 5.249

4. Haemostatic factors and ischaemic heart disease. The Caerphilly study.

Authors: J W Yarnell; P M Sweetnam; P C Elwood; R Eastham; R A Gilmour; J R O'Brien; M D Etherington
Journal: Br Heart J Date: 1985-05

5. Increased fibrinopeptide A formation and thromboxane A2 production in patients with ischemic heart disease: relationships to coronary pathoanatomy, risk factors, and clinical manifestations.

Authors: G G Neri Serneri; G F Gensini; R Abbate; C Mugnaini; S Favilla; C Brunelli; S Chierchia; O Parodi
Journal: Am Heart J Date: 1981-02 Impact factor: 4.749

Thrombin and plasmin activity in coronary artery disease.

1. Plasma beta-thromboglobulin, fibrinopeptide A and B beta 15-42 antigen in relation to postoperative DVT, malignancy and stanozolol treatment.

2. ABC of nutrition. Obesity: diagnosis and risks.

3. Haemostatic variables and the outcome of myocardial infarction.

4. Haemostatic factors and ischaemic heart disease. The Caerphilly study.

5. Increased fibrinopeptide A formation and thromboxane A2 production in patients with ischemic heart disease: relationships to coronary pathoanatomy, risk factors, and clinical manifestations.

6. Fibrinopeptide A, platelet factor 4, and beta-thromboglobulin levels in coronary heart disease.

7. Plasma fibrinopeptide A and beta-thromboglobulin in patients with chest pain.

8. Fibrinogen as a risk factor for stroke and myocardial infarction.

9. Activation of coagulation and fibrinolytic systems following stroke.

10. Relative proteolysis of the fibrinogen B beta chain by thrombin and plasmin as a determinant of thrombosis.

1. Enhanced thrombolytic efficacy and reduction of infarct size by simultaneous infusion of streptokinase and heparin.