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Literature DB >> 29722551

Placentation-related processes in a human first-trimester extravillous trophoblast cell line (HTR-8/SVneo cells) are affected by several xenobiotics.

Ana Correia-Branco^1,2, Elisa Keating^1,3, Fátima Martel^1,2.

Abstract

Our aim was to investigate the effect of some xenobiotics on placentation-related processes in an extravillous trophoblastic cell line (HTR-8/SVneo cells). Amphetamine, MDMA, theophylline, and fluoxetine, but not nicotine, cocaine, and caffeine, had a negative effect on cell proliferation rates, culture growth, viability, or migratory capacity. These compounds have a detrimental effect in placentation-related processes of HTR-8/SVneo cells.

Entities: Chemical Species

Keywords: Extravillous trophoblasts; HTR-8/SVneo cell line; migration; proliferation; viability; xenobiotics

Year: 2018 PMID： 29722551 DOI： 10.1080/01480545.2018.1463240

Source DB: PubMed Journal: Drug Chem Toxicol ISSN： 0148-0545 Impact factor: 3.356

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Cited

3 in total

Placentation-related processes in a human first-trimester extravillous trophoblast cell line (HTR-8/SVneo cells) are affected by several xenobiotics.

1. The impact of tobacco chemicals and nicotine on placental development.

2. Understanding the Placental Biology of Tobacco Smoke, Nicotine, and Marijuana (THC) Exposures During Pregnancy.

3. α-Solanine Causes Cellular Dysfunction of Human Trophoblast Cells via Apoptosis and Autophagy.