Literature DB >> 29722274

Statins use and cancer: an update.

Martyna Zaleska1, Olga Mozenska1, Jacek Bil2.   

Abstract

After initial concerns regarding the association of statins with increased incidences of cancer and elevated cancer-related mortality, there are now plenty of data on the antitumor, cytostatic and cytotoxic effectiveness of this class of drugs. Here, we present a short review of possible mechanisms of antineoplastic activity obtained from preclinical research and the influence of statins on cancer treatment. In the second part of the article, we focus on the most recent data from observational clinical trials, as well as meta-analyses regarding cancer incidence and mortality in patients treated with statins.

Entities:  

Keywords:  HMG-CoA reductase inhibitors; antitumor activity; cancer treatment; mevalonate pathway; statins

Mesh：

Substances：

Year:  2018        PMID： 29722274     DOI： 10.2217/fon-2017-0543

Source DB:  PubMed          Journal:  Future Oncol        ISSN： 1479-6694            Impact factor:   3.404


  13 in total

Review 1.  Deprescribing in Palliative Cancer Care.

Authors:  Christel Hedman; Gabriella Frisk; Linda Björkhem-Bergman
Journal:  Life (Basel)       Date:  2022-04-20

2.  Pooled Cohort Equations and the competing risk of cardiovascular disease versus cancer: Multi-Ethnic study of atherosclerosis.

Authors:  Seamus P Whelton; Catherine Handy Marshall; Miguel Cainzos-Achirica; Omar Dzaye; Roger S Blumenthal; Khurram Nasir; Robyn L McClelland; Michael J Blaha
Journal:  Am J Prev Cardiol       Date:  2021-06-14

Review 3.  Exercise and immunometabolic regulation in cancer.

Authors:  Graeme J Koelwyn; Xueqian Zhuang; Tuomas Tammela; Andrea Schietinger; Lee W Jones
Journal:  Nat Metab       Date:  2020-09-14

Review 4.  Targeting the Mevalonate Pathway in Cancer.

Authors:  Dennis Juarez; David A Fruman
Journal:  Trends Cancer       Date:  2021-01-06

5.  Gastric cancer cells escape metabolic stress via the DLC3/MACC1 axis.

Authors:  Li Lin; Yantan Liu; Changqie Pan; Junhao Zhang; Yang Zhao; Ruoyang Shao; Zhenhua Huang; Yuqi Su; Min Shi; Jianping Bin; Yulin Liao; Nailin Li; Chunlin Wang; Wangjun Liao
Journal:  Theranostics       Date:  2019-04-06       Impact factor: 11.556

6.  Cholesterol as an Endogenous Ligand of ERRα Promotes ERRα-Mediated Cellular Proliferation and Metabolic Target Gene Expression in Breast Cancer Cells.

Authors:  Faegheh Ghanbari; Sylvie Mader; Anie Philip
Journal:  Cells       Date:  2020-07-23       Impact factor: 6.600

7.  Sex-Differences in Discontinuation of Statin Treatment in Cancer Patients the Year before Death.

Authors:  Gabriella Frisk; Helena Bergström; Maria Helde Frankling; Linda Björkhem-Bergman
Journal:  Pharmaceuticals (Basel)       Date:  2021-04-16

8.  Cholesterol-Induced Metabolic Reprogramming in Breast Cancer Cells Is Mediated via the ERRα Pathway.

Authors:  Faegheh Ghanbari; Anne-Marie Fortier; Morag Park; Anie Philip
Journal:  Cancers (Basel)       Date:  2021-05-26       Impact factor: 6.639

Review 9.  Cholesterol as an Endogenous ERRα Agonist: A New Perspective to Cancer Treatment.

Authors:  Ivan Casaburi; Adele Chimento; Arianna De Luca; Marta Nocito; Sara Sculco; Paola Avena; Francesca Trotta; Vittoria Rago; Rosa Sirianni; Vincenzo Pezzi
Journal:  Front Endocrinol (Lausanne)       Date:  2018-09-11       Impact factor: 5.555

Review 10.  Development of Cancer in Patients With Heart Failure: How Systemic Inflammation Can Lay the Groundwork.

Authors:  Simonetta Ausoni; Giuseppe Azzarello
Journal:  Front Cardiovasc Med       Date:  2020-10-26
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