Literature DB >> 29721966

Impact of MCT1 Haploinsufficiency on the Mouse Retina.

Neal S Peachey1,2,3, Minzhong Yu4,5, John Y S Han6, Sylvain Lengacher7, Pierre J Magistretti7,8, Luc Pellerin9, Nancy J Philp6.   

Abstract

The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1 +/- heterozygotes, which express half of the normal complement of MCT1. The MCT1 +/- retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.

Entities:  

Keywords:  Electroretinogram; Lactate; MCT1; Retina; Transgenic mice

Mesh：

Substances：

Year:  2018        PMID： 29721966      PMCID： PMC6708593          DOI： 10.1007/978-3-319-75402-4_46

Source DB:  PubMed          Journal:  Adv Exp Med Biol        ISSN： 0065-2598            Impact factor:   2.622


  13 in total

1.  CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression.

Authors:  P Kirk; M C Wilson; C Heddle; M H Brown; A N Barclay; A P Halestrap
Journal:  EMBO J       Date:  2000-08-01       Impact factor: 11.598

2.  The Warburg hypothesis fifty years later.

Authors:  S Weinhouse
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976

Review 3.  The SLC16A family of monocarboxylate transporters (MCTs)--physiology and function in cellular metabolism, pH homeostasis, and fluid transport.

Authors:  Jeffrey Adijanto; Nancy J Philp
Journal:  Curr Top Membr       Date:  2012       Impact factor: 3.049

4.  Uncovering microdeletions in patients with severe Glut-1 deficiency syndrome using SNP oligonucleotide microarray analysis.

Authors:  Brynn Levy; Dong Wang; Paivi M Ullner; Kristin Engelstad; Hong Yang; Odelia Nahum; Wendy K Chung; Darryl C De Vivo
Journal:  Mol Genet Metab       Date:  2010-03-17       Impact factor: 4.797

5.  Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia.

Authors:  Minzhong Yu; Gwen Sturgill-Short; Preethi Ganapathy; Amany Tawfik; Neal S Peachey; Sylvia B Smith
Journal:  Exp Eye Res       Date:  2011-12-16       Impact factor: 3.467

6.  Retinal dysfunction in basigin deficiency.

Authors:  K Hori; N Katayama; S Kachi; M Kondo; K Kadomatsu; J Usukura; T Muramatsu; S Mori; Y Miyake
Journal:  Invest Ophthalmol Vis Sci       Date:  2000-09       Impact factor: 4.799

Review 7.  Sweet sixteen for ANLS.

Authors:  Luc Pellerin; Pierre J Magistretti
Journal:  J Cereb Blood Flow Metab       Date:  2011-10-26       Impact factor: 6.200

8.  Glial (Müller) cells take up and phosphorylate [3H]2-deoxy-D-glucose in mammalian retina.

Authors:  C Poitry-Yamate; M Tsacopoulos
Journal:  Neurosci Lett       Date:  1991-01-28       Impact factor: 3.046

9.  Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse.

Authors:  Nancy J Philp; Judith D Ochrietor; Carla Rudoy; Takashi Muramatsu; Paul J Linser
Journal:  Invest Ophthalmol Vis Sci       Date:  2003-03       Impact factor: 4.799

10.  Oligodendroglia metabolically support axons and contribute to neurodegeneration.

Authors:  Youngjin Lee; Brett M Morrison; Yun Li; Sylvain Lengacher; Mohamed H Farah; Paul N Hoffman; Yiting Liu; Akivaga Tsingalia; Lin Jin; Ping-Wu Zhang; Luc Pellerin; Pierre J Magistretti; Jeffrey D Rothstein
Journal:  Nature       Date:  2012-07-26       Impact factor: 49.962
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  1 in total

1.  Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: Insight gained from cell-specific Bsg deletion.

Authors:  John Y S Han; Junzo Kinoshita; Sara Bisetto; Brent A Bell; Romana A Nowak; Neal S Peachey; Nancy J Philp
Journal:  FASEB J       Date:  2020-02-28       Impact factor: 5.191
  1 in total

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