| Literature DB >> 29721363 |
Andrew S Lee1,2,3,4,5, Mohammed Inayathullah1,4,5, Maarten A Lijkwan1, Xin Zhao1, Wenchao Sun1,2,3,4,5, Sujin Park1,2,3, Wan Xing Hong1,2,3, Mansi B Parekh4, Andrey V Malkovskiy4, Edward Lau1, Xulei Qin1, Venkata Raveendra Pothineni4, Verónica Sanchez-Freire1,2,3, Wendy Y Zhang1,2,3, Nigel G Kooreman1,2,3, Antje D Ebert1,2,3, Charles K F Chan2,6, Patricia K Nguyen7,8, Jayakumar Rajadas9,10,11, Joseph C Wu12,13,14,15.
Abstract
Stem-cell-based therapies hold considerable promise for regenerative medicine. However, acute donor-cell death within several weeks after cell delivery remains a critical hurdle for clinical translation. Co-transplantation of stem cells with pro-survival factors can improve cell engraftment, but this strategy has been hampered by the typically short half-lives of the factors and by the use of Matrigel and other scaffolds that are not chemically defined. Here, we report a collagen-dendrimer biomaterial crosslinked with pro-survival peptide analogues that adheres to the extracellular matrix and slowly releases the peptides, significantly prolonging stem cell survival in mouse models of ischaemic injury. The biomaterial can serve as a generic delivery system to improve functional outcomes in cell-replacement therapy.Entities:
Year: 2018 PMID： 29721363 PMCID： PMC5927627 DOI： 10.1038/s41551-018-0191-4
Source DB: PubMed Journal: Nat Biomed Eng ISSN： 2157-846X Impact factor: 25.671