Author's Reply.

We would like to elaborate our response to the valued views of the authors of this letter as follows. In our study,[1] we looked only at the mutations in SOD1 and VSX. We agree with Dr. Beuy Joob and Dr. Viroj Wiwanitkit that the negative results might be because of the small sample size, and therefore, epigenetic mechanisms or other loci should be investigated using NGS for these cases. Finally, we assure readers about the quality control of the laboratory tests as our laboratory is one of the main centers in Iran that performs high quality genetic tests for diagnostic purposes.

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Conflict of Interest

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