Literature DB >> 29719430

Intravenous vitamin C in the supportive care of cancer patients: a review and rational approach.

E Klimant1, H Wright2, D Rubin2, D Seely3, M Markman4.   

Abstract

This article reviews intravenous vitamin C (IV C) in cancer care and offers a rational approach to enable medical oncologists and integrative practitioners to safely provide IV C combined with oral vitamin C to patients. The use of IV C is a safe supportive intervention to decrease inflammation in the patient and to improve symptoms related to antioxidant deficiency, disease processes, and side effects of standard cancer treatments. A proposed rationale, together with relevant clinical safety considerations for the application of IV C in oncologic supportive care, is provided.

Entities:  

Keywords:  Vitamin C deficiency; ascorbate; intravenous vitamin C; quality of life; supportive care

Mesh：

Substances：

Year:  2018        PMID： 29719430      PMCID： PMC5927785          DOI： 10.3747/co.25.3790

Source DB:  PubMed          Journal:  Curr Oncol        ISSN： 1198-0052            Impact factor:   3.677


  83 in total

1.  Intravenous vitamin C can improve anemia in erythropoietin-hyporesponsive hemodialysis patients.

Authors:  Claude Jacobs
Journal:  Nat Clin Pract Nephrol       Date:  2006-10

2.  Concentrations of ascorbic acid in plasma and white blood cells of patients with cancer and noncancerous chronic disease.

Authors:  O BODANSKY; F WROBLEWSKI; B MARKARDT
Journal:  Cancer       Date:  1952-07       Impact factor: 6.860

3.  High-dose parenteral ascorbate enhanced chemosensitivity of ovarian cancer and reduced toxicity of chemotherapy.

Authors:  Yan Ma; Julia Chapman; Mark Levine; Kishore Polireddy; Jeanne Drisko; Qi Chen
Journal:  Sci Transl Med       Date:  2014-02-05       Impact factor: 17.956

4.  Intake of vitamins B6 and C and the risk of kidney stones in women.

Authors:  G C Curhan; W C Willett; F E Speizer; M J Stampfer
Journal:  J Am Soc Nephrol       Date:  1999-04       Impact factor: 10.121

5.  Serum carotene, vitamin A, and vitamin C levels in breast cancer and cancer of the uterine cervix.

Authors:  G Ramaswamy; L Krishnamoorthy
Journal:  Nutr Cancer       Date:  1996       Impact factor: 2.900

6.  THE MECHANISM OF THE EXCRETION OF VITAMIN C BY THE HUMAN KIDNEY AT LOW AND NORMAL PLASMA LEVELS OF ASCORBIC ACID.

Authors:  G J Friedman; S Sherry; E P Ralli
Journal:  J Clin Invest       Date:  1940-09       Impact factor: 14.808

Review 7.  [Vitamin C].

Authors:  Olivier Fain
Journal:  Rev Prat       Date:  2013-10

8.  Trace element supplementation after major burns modulates antioxidant status and clinical course by way of increased tissue trace element concentrations.

Authors:  Mette M Berger; Malcolm Baines; Wassim Raffoul; Messod Benathan; René L Chiolero; Chris Reeves; Jean-Pierre Revelly; Marie-Christine Cayeux; Isabelle Sénéchaud; Alan Shenkin
Journal:  Am J Clin Nutr       Date:  2007-05       Impact factor: 7.045

9.  Phase I evaluation of intravenous ascorbic acid in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer.

Authors:  Daniel A Monti; Edith Mitchell; Anthony J Bazzan; Susan Littman; George Zabrecky; Charles J Yeo; Madhaven V Pillai; Andrew B Newberg; Sandeep Deshmukh; Mark Levine
Journal:  PLoS One       Date:  2012-01-17       Impact factor: 3.240

10.  Effect of high-dose intravenous vitamin C on inflammation in cancer patients.

Authors:  Nina Mikirova; Joseph Casciari; Andrea Rogers; Paul Taylor
Journal:  J Transl Med       Date:  2012-09-11       Impact factor: 5.531
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  22 in total

Review 1.  Targeting cancer vulnerabilities with high-dose vitamin C.

Authors:  Bryan Ngo; Justin M Van Riper; Lewis C Cantley; Jihye Yun
Journal:  Nat Rev Cancer       Date:  2019-05       Impact factor: 60.716

Review 2.  Oxidative stress in bladder cancer: an ally or an enemy?

Authors:  Fernando Mendes; Eurico Pereira; Diana Martins; Edgar Tavares-Silva; Ana Salomé Pires; Ana Margarida Abrantes; Arnaldo Figueiredo; Maria Filomena Botelho
Journal:  Mol Biol Rep       Date:  2021-03-17       Impact factor: 2.316

3.  Administration of Intravenous Ascorbic Acid-Practical Considerations for Clinicians.

Authors:  Scott E Walker; John Iazzetta; Shirley Law; Salmaan Kanji; Brigitte Bolduc; François Lamontagne; Neill K J Adhikari
Journal:  Nutrients       Date:  2019-08-23       Impact factor: 5.717

4.  Tumor suppressor TET2 promotes cancer immunity and immunotherapy efficacy.

Authors:  Yan-Ping Xu; Lei Lv; Ying Liu; Matthew D Smith; Wen-Cai Li; Xian-Ming Tan; Meng Cheng; Zhijun Li; Michael Bovino; Jeffrey Aubé; Yue Xiong
Journal:  J Clin Invest       Date:  2019-07-16       Impact factor: 14.808

Review 5.  The benefits of ascorbate to protect healthy cells in the prevention and treatment of oncological diseases.

Authors:  Pavel Klener; Matthew Scott Alexander; Joseph John Cullen; Vera Stejskal; Jiri Sliva; Lucie Kotlarova; Pavel Kostiuk; Zdenek Prochazka; Marta Kucerova
Journal:  J Appl Biomed       Date:  2020-02-19       Impact factor: 1.797

Review 6.  Micro but mighty-Micronutrients in the epigenetic regulation of adaptive immune responses.

Authors:  Heng-Yi Chen; Michael Hsu; Chan-Wang Jerry Lio
Journal:  Immunol Rev       Date:  2021-11-24       Impact factor: 12.988

7.  Epigenetic remodeling by vitamin C potentiates plasma cell differentiation.

Authors:  Heng-Yi Chen; Ana Almonte-Loya; Fang-Yun Lay; Michael Hsu; Eric Johnson; Edahí González-Avalos; Jieyun Yin; Richard S Bruno; Qin Ma; Hazem E Ghoneim; Daniel J Wozniak; Fiona E Harrison; Chan-Wang Jerry Lio
Journal:  Elife       Date:  2022-09-07       Impact factor: 8.713

Review 8.  High-Dose Vitamin C for Cancer Therapy.

Authors:  Ali Mussa; Ros Akmal Mohd Idris; Naveed Ahmed; Suhana Ahmad; Ahmad Hafiz Murtadha; Tengku Ahmad Damitri Al Astani Tengku Din; Chan Yean Yean; Wan Faiziah Wan Abdul Rahman; Norhafiza Mat Lazim; Vuk Uskoković; Khalid Hajissa; Noor Fatmawati Mokhtar; Rohimah Mohamud; Rosline Hassan
Journal:  Pharmaceuticals (Basel)       Date:  2022-06-03

Review 9.  Ascorbic Acid in Colon Cancer: From the Basic to the Clinical Applications.

Authors:  Ibrahim El Halabi; Rachelle Bejjany; Rihab Nasr; Deborah Mukherji; Sally Temraz; Farah J Nassar; Haidar El Darsa; Ali Shamseddine
Journal:  Int J Mol Sci       Date:  2018-09-13       Impact factor: 5.923

Review 10.  Current Understanding of the Emerging Role of Prolidase in Cellular Metabolism.

Authors:  Magdalena Misiura; Wojciech Miltyk
Journal:  Int J Mol Sci       Date:  2020-08-17       Impact factor: 5.923
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