Chao Xu1, Linfeng Zheng2, Dechuan Li3, Guoping Chen2, Jianzhong Gu4, Jun Chen5, Qinghua Yao6. 1. Department of Integrated Chinese and Western Medicine, Zhejiang Cancer Hospital, Hangzhou 310022, China. 2. Department of Pathology, Zhejiang Cancer Hospital, Hangzhou 310022, China. 3. Department of Colorectal Surgery, Zhejiang Cancer Hospital, Hangzhou 310022, China. 4. Department of Oncology, First Affiliated Hospital of Zhejiang Traditional Medical University, Hangzhou 310003, China. 5. Department of Oncology, Yinzhou Hospital affiliated to Medical School of Ningbo University, Ningbo 315040, China. Electronic address: cj@nbyzyy.com. 6. Department of Integrated Chinese and Western Medicine, Zhejiang Cancer Hospital, Hangzhou 310022, China. Electronic address: Yaoqh@zjcc.org.cn.
Abstract
AIMS: Colorectal cancer threatens human health due to its high mortality resulting from metastatic progression. The expression of C-X-C chemokine receptor type 4 (CXCR4) is absent or low in most healthy tissues but high in various types of tumours. In this study, we aim to determine the prognostic significance of CXCR4 in colorectal cancer. MAIN METHODS: We retrospectively examined a total of 72 tissue samples, that qRT-PCR and immunohistochemistry were performed to detect the expression of CXCR4 as well as univariate and multivariate analyses were performed to explore the overall survival. KEY FINDINGS: Our data demonstrated that CXCR4 expression was associated with lymph node metastasis (P = 0.049), histological differentiation (P = 0.01), distant metastasis (P = 0.02) and DNA mismatch repair (MMR) index (P = 0.0002). However, CXCR4 expression was not associated with age, sex, tumour diameter or depth of invasion. Furthermore, both univariate and multivariate analyses confirmed that CXCR4 was an independent factor in predicting unfavourable overall survival (hazard ratio, 0.188; 95% confidence interval, 0.038-0.757). SIGNIFICANCE: In conclusion, our findings suggest that CXCR4 might contribute to clinical tumour progression and may be a valuable prognostic biomarker in colorectal cancer treatment.
AIMS: Colorectal cancer threatens human health due to its high mortality resulting from metastatic progression. The expression of C-X-C chemokine receptor type 4 (CXCR4) is absent or low in most healthy tissues but high in various types of tumours. In this study, we aim to determine the prognostic significance of CXCR4 in colorectal cancer. MAIN METHODS: We retrospectively examined a total of 72 tissue samples, that qRT-PCR and immunohistochemistry were performed to detect the expression of CXCR4 as well as univariate and multivariate analyses were performed to explore the overall survival. KEY FINDINGS: Our data demonstrated that CXCR4 expression was associated with lymph node metastasis (P = 0.049), histological differentiation (P = 0.01), distant metastasis (P = 0.02) and DNA mismatch repair (MMR) index (P = 0.0002). However, CXCR4 expression was not associated with age, sex, tumour diameter or depth of invasion. Furthermore, both univariate and multivariate analyses confirmed that CXCR4 was an independent factor in predicting unfavourable overall survival (hazard ratio, 0.188; 95% confidence interval, 0.038-0.757). SIGNIFICANCE: In conclusion, our findings suggest that CXCR4 might contribute to clinical tumour progression and may be a valuable prognostic biomarker in colorectal cancer treatment.
Authors: Javier Molina-Cerrillo; María San Román; Javier Pozas; Teresa Alonso-Gordoa; Miguel Pozas; Elisa Conde; Marta Rosas; Enrique Grande; María Laura García-Bermejo; Alfredo Carrato Journal: Cancers (Basel) Date: 2020-06-14 Impact factor: 6.639