Literature DB >> 29718674

Enantioselective Total Synthesis of Natural Isoflavans: Asymmetric Transfer Hydrogenation/Deoxygenation of Isoflavanones with Dynamic Kinetic Resolution.

Anton Keßberg1, Tilo Lübken1, Peter Metz1.   

Abstract

A concise and highly enantioselective synthesis of structurally diverse isoflavans from a single chromone is described. The key transformation is a single-step conversion of racemic isoflavanones into virtually enantiopure isoflavans by domino asymmetric transfer hydrogenation/deoxygenation with dynamic kinetic resolution.

Entities:  

Year:  2018        PMID： 29718674     DOI： 10.1021/acs.orglett.8b01034

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Enantioselective Synthesis of Homoisoflavanones by Asymmetric Transfer Hydrogenation and Their Biological Evaluation for Antiangiogenic Activity.

Authors:  Myunghoe Heo; Bit Lee; Kamakshi Sishtla; Xiang Fei; Sanha Lee; Soojun Park; Yue Yuan; Seul Lee; Sangil Kwon; Jungeun Lee; Sanghee Kim; Timothy W Corson; Seung-Yong Seo
Journal:  J Org Chem       Date:  2019-08-05       Impact factor: 4.354

2.  Asymmetric one-pot transformation of isoflavones to pterocarpans and its application in phytoalexin synthesis.

Authors:  Philipp Ciesielski; Peter Metz
Journal:  Nat Commun       Date:  2020-06-18       Impact factor: 14.919

3.  Antifungal Activity of Chemical Constituents from Piper pesaresanum C. DC. and Derivatives against Phytopathogen Fungi of Cocoa.

Authors:  Luis C Chitiva-Chitiva; Cristóbal Ladino-Vargas; Luis E Cuca-Suárez; Juliet A Prieto-Rodríguez; Oscar J Patiño-Ladino
Journal:  Molecules       Date:  2021-05-28       Impact factor: 4.411
  3 in total

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