| Literature DB >> 29718342 |
Mark J Siedner1,2,3, Markella Zanni1,2, Russell P Tracy4, Douglas S Kwon1,2, Alexander C Tsai1,2, Bernard Kakuhire3, Peter W Hunt5, Samson Okello6,7,3.
Abstract
In a cohort of human immunodeficiency virus (HIV)-infected individuals and age- and sex-matched HIV-uninfected comparators, we assessed soluble CD14 (sCD14), sCD163, interleukin 6, intestinal fatty acid binding protein (IFAPB), and high-sensitivity C-reactive protein (hs-CRP) levels. The median age was 51 years. Among HIV-positive individuals, the median antiretroviral therapy (ART) duration was 7 years, the median CD4+ T-cell count was 433 cells/μL, and 86% had an undetectable viral load. Although HIV-positive individuals had higher sCD14, IFABP, and hs-CRP levels, we found evidence of interaction by sex, such that HIV-positive women had greater differences from HIV-negative women, compared with differences between HIV-positive men and HIV-negative men. In models restricted to HIV-positive individuals, women had higher levels of all 5 biomarkers than men.Entities:
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Year: 2018 PMID： 29718342 PMCID： PMC6093434 DOI： 10.1093/infdis/jiy244
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 7.759