| Literature DB >> 29717993 |
Michael S Little1, Matthew R Redinbo1.
Abstract
Bacterial permeability-increasing family member A1 (BPIFA1) is an innate immunity factor and one of the most abundantly secreted proteins in the upper airways. BPIFA1 is multifunctional, with antimicrobial, surfactant and lipopolysaccharide-binding activities, as well as established roles in lung hydration. Here, the 2.5 Å resolution crystal structure of BPIFA1 from Mus musculus (mBPIFA1) is presented and compared with those of human BPIFA1 (hBPIFA1) and structural homologs. Structural distinctions between mBPIFA1 and hBPIFA1 suggest potential differences in biological function, including the regulation of a key pulmonary ion channel.Entities:
Keywords: BPIFA1; Mus musculus; antimicrobial proteins; bacterial permeability-increasing family member A1; biological chemistry; innate immunity proteins; lung biology; protein surfactants; pulmonary proteins; structural biology; surfactant proteins
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Year: 2018 PMID： 29717993 PMCID： PMC5931138 DOI： 10.1107/S2053230X18004600
Source DB: PubMed Journal: Acta Crystallogr F Struct Biol Commun ISSN： 2053-230X Impact factor: 1.056