Gregory P Barton1,2, Lauren Vildberg3,4, Kara Goss3,5,4, Niti Aggarwal6,7, Marlowe Eldridge3,8,4, Alan B McMillan7. 1. Department of Pediatrics, UW School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave. H6/551 CSC, Madison, WI, 53792, USA. gpbarton@pediatrics.wisc.edu. 2. Rankin Laboratory of Pulmonary Medicine, University of Wisconsin-Madison, Madison, USA. gpbarton@pediatrics.wisc.edu. 3. Department of Pediatrics, UW School of Medicine and Public Health, University of Wisconsin-Madison, 600 Highland Ave. H6/551 CSC, Madison, WI, 53792, USA. 4. Rankin Laboratory of Pulmonary Medicine, University of Wisconsin-Madison, Madison, USA. 5. Department of Medicine, University of Wisconsin-Madison, Madison, USA. 6. Division of Cardiovascular Disease Department of Medicine, University of Wisconsin-Madison, Madison, USA. 7. Department of Radiology, University of Wisconsin-Madison, Madison, USA. 8. Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, USA.
Abstract
BACKGROUND: Cardiac metabolic changes in heart disease precede overt contractile dysfunction. However, metabolism and function are not typically assessed together in clinical practice. The purpose of this study was to develop a cardiac positron emission tomography/magnetic resonance (PET/MR) stress test to assess the dynamic relationship between contractile function and metabolism in a preclinical model. METHODS: Following an overnight fast, healthy pigs (45-50 kg) were anesthetized and mechanically ventilated. 18F-fluorodeoxyglucose (18F-FDG) solution was administered intravenously at a constant rate of 0.01 mL/s for 60 minutes. A cardiac PET/MR stress test was performed using normoxic gas (FIO2 = .209) and hypoxic gas (FIO2 = .12). Simultaneous cardiac imaging was performed on an integrated 3T PET/MR scanner. RESULTS: Hypoxic stress induced a significant increase in heart rate, cardiac output, left ventricular (LV) ejection fraction (EF), and peak torsion. There was a significant decline in arterial SpO2, LV end-diastolic and end-systolic volumes in hypoxia. Increased LV systolic function was coupled with an increase in myocardial FDG uptake (Ki) during hypoxic stress. CONCLUSION: PET/MR with continuous FDG infusion captures dynamic changes in both cardiac metabolism and contractile function. This technique warrants evaluation in human cardiac disease for assessment of subtle functional and metabolic abnormalities.
BACKGROUND: Cardiac metabolic changes in heart disease precede overt contractile dysfunction. However, metabolism and function are not typically assessed together in clinical practice. The purpose of this study was to develop a cardiac positron emission tomography/magnetic resonance (PET/MR) stress test to assess the dynamic relationship between contractile function and metabolism in a preclinical model. METHODS: Following an overnight fast, healthy pigs (45-50 kg) were anesthetized and mechanically ventilated. 18F-fluorodeoxyglucose (18F-FDG) solution was administered intravenously at a constant rate of 0.01 mL/s for 60 minutes. A cardiac PET/MR stress test was performed using normoxic gas (FIO2 = .209) and hypoxic gas (FIO2 = .12). Simultaneous cardiac imaging was performed on an integrated 3T PET/MR scanner. RESULTS:Hypoxic stress induced a significant increase in heart rate, cardiac output, left ventricular (LV) ejection fraction (EF), and peak torsion. There was a significant decline in arterial SpO2, LV end-diastolic and end-systolic volumes in hypoxia. Increased LV systolic function was coupled with an increase in myocardial FDG uptake (Ki) during hypoxic stress. CONCLUSION: PET/MR with continuous FDG infusion captures dynamic changes in both cardiac metabolism and contractile function. This technique warrants evaluation in humancardiac disease for assessment of subtle functional and metabolic abnormalities.
Entities:
Keywords:
MRI; PET; Physiology of LV/RV function; metabolic
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