Literature DB >> 2971567

Cloning and sequence analysis of a cDNA encoding the beta-subunit of mouse beta-hexosaminidase.

B Bapat1, M Ethier, K Neote, D Mahuran, R A Gravel.   

Abstract

A cDNA encoding the prepro-beta-polypeptide of mouse beta-hexosaminidase (Hex) was isolated from a mouse lymphoblast cDNA library. The cDNA contains an open reading frame corresponding to a polypeptide of 536 amino acids which shows 74% homology with the human prepro-beta-polypeptide. An examination of the amino acid sequence identifies a putative signal peptide and five possible glycosylation sites, two of which are identical to the confirmed glycosylation sites of the human beta-chain. The amino acid sequence also shows a structurally similar though not identical site for internal cleavage responsible for the generation of mature beta a- and beta b-polypeptides.

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Year:  1988        PMID： 2971567     DOI： 10.1016/0014-5793(88)80199-6

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  15 in total

1.  Cloning and sequence analysis of a cDNA encoding the alpha-subunit of mouse beta-N-acetylhexosaminidase and comparison with the human enzyme.

Authors:  T Beccari; J Hoade; A Orlacchio; J L Stirling
Journal:  Biochem J       Date:  1992-07-15       Impact factor: 3.857

2.  Cloning and sequence analysis of a cDNA clone coding for the mouse GM2 activator protein.

Authors:  G Bellachioma; J L Stirling; A Orlacchio; T Beccari
Journal:  Biochem J       Date:  1993-08-15       Impact factor: 3.857

Review 3.  The natural history of juvenile or subacute GM2 gangliosidosis: 21 new cases and literature review of 134 previously reported.

Authors:  Gustavo H B Maegawa; Tracy Stockley; Michael Tropak; Brenda Banwell; Susan Blaser; Fernando Kok; Roberto Giugliani; Don Mahuran; Joe T R Clarke
Journal:  Pediatrics       Date:  2006-10-02       Impact factor: 7.124

4.  Isolation and sequence analysis of a cDNA encoding rat liver alpha-L-fucosidase.

Authors:  K J Fisher; N N Aronson
Journal:  Biochem J       Date:  1989-12-15       Impact factor: 3.857

5.  Sequence analysis of the beta-N-acetylhexosaminidase gene of Vibrio vulnificus: evidence for a common evolutionary origin of hexosaminidases.

Authors:  C C Somerville; R R Colwell
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-15       Impact factor: 11.205

6.  Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs disease.

Authors:  M Cohen-Tannoudji; P Marchand; S Akli; S A Sheardown; J P Puech; C Kress; P Gressens; M C Nassogne; T Beccari; A L Muggleton-Harris
Journal:  Mamm Genome       Date:  1995-12       Impact factor: 2.957

7.  Gene transfer corrects acute GM2 gangliosidosis--potential therapeutic contribution of perivascular enzyme flow.

Authors:  M Begoña Cachón-González; Susan Z Wang; Rosamund McNair; Josephine Bradley; David Lunn; Robin Ziegler; Seng H Cheng; Timothy M Cox
Journal:  Mol Ther       Date:  2012-03-27       Impact factor: 11.454

8.  Molecular cloning and functional characterization of beta-N-acetylglucosaminidase genes from Sf9 cells.

Authors:  Jared J Aumiller; Jason R Hollister; Donald L Jarvis
Journal:  Protein Expr Purif       Date:  2005-12-27       Impact factor: 1.650

9.  Molecular cloning and expression of the Candida albicans beta-N-acetylglucosaminidase (HEX1) gene.

Authors:  R D Cannon; K Niimi; H F Jenkinson; M G Shepherd
Journal:  J Bacteriol       Date:  1994-05       Impact factor: 3.490

10.  Two new mutations in a late infantile Tay-Sachs patient are both in exon 1 of the beta-hexosaminidase alpha subunit gene.

Authors:  D L Harmon; D Gardner-Medwin; J L Stirling
Journal:  J Med Genet       Date:  1993-02       Impact factor: 6.318
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