Azza Saad Ibrahim1, Mona Mohamed Eldeeb2, Ola Ahmed Salama3, Mona Mohamed Rashad4, Khaled Mohamed Okasha4. 1. Medical Research Institute, Alexandria University, Alexandria, Egypt. 2. Department of Chemical Pathology, Medical Research Institute, Alexandria University, Alexandria, Egypt. 3. Department of Physiology, Medical Research Institute, Alexandria University, Alexandria, Egypt. 4. Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.
Abstract
OBJECTIVES: Helicobacter pylori (H. pylori) is a common gastric infection associated with extragastric conditions. The association between H. pylori infection and obesity is unclear. H. pylori may affect gut hormones involved in food intake and energy expenditure. The aim of this study is to evaluate ghrelin/obestatin balance and leptin in obese subjects with H. pylori infection. METHODS: Sixty healthy volunteers were divided into: obese and non-obese groups. Each group was divided into H. Pylori positive or H. pylori negative. Anthropometric parameters, H. pylori status, serum glucose, insulin level, and lipid profile were estimated with calculation of Homeostasis Model Assessment Insulin Resistance (HOMA-IR). Serum levels of ghrelin, obestatin, and leptin were evaluated. RESULTS: Significant increase was found in serum glucose, insulin and HOMA-IR ratio in obese subjects with positive H. pylori as compared to other groups. H. pylori positive obese subjects showed significantly increased ghrelin, ghrelin/obestatin balance, and leptin with a significant decrease in obestatin as compared to negative subjects. Ghrelin/obestatin ratio positively correlated with weight, body mass index, waist, glucose, insulin, HOMA-IR, leptin, cholesterol, triglycerides, low density cholesterol and also with H. pylori antigen in the same group. CONCLUSIONS: It can be concluded that ghrelin, obestatin, and leptin are affected by presence of H. pylori seropositivity in obese subjects. The higher ghrelin levels and ghrelin/obestatin ratio with lowered obestatin could be considered as a gastro-protective effect against inflammation induced by H. pylori.
OBJECTIVES:Helicobacter pylori (H. pylori) is a common gastric infection associated with extragastric conditions. The association between H. pyloriinfection and obesity is unclear. H. pylori may affect gut hormones involved in food intake and energy expenditure. The aim of this study is to evaluate ghrelin/obestatin balance and leptin in obese subjects with H. pyloriinfection. METHODS: Sixty healthy volunteers were divided into: obese and non-obese groups. Each group was divided into H. Pylori positive or H. pylori negative. Anthropometric parameters, H. pylori status, serum glucose, insulin level, and lipid profile were estimated with calculation of Homeostasis Model Assessment Insulin Resistance (HOMA-IR). Serum levels of ghrelin, obestatin, and leptin were evaluated. RESULTS: Significant increase was found in serum glucose, insulin and HOMA-IR ratio in obese subjects with positive H. pylori as compared to other groups. H. pylori positive obese subjects showed significantly increased ghrelin, ghrelin/obestatin balance, and leptin with a significant decrease in obestatin as compared to negative subjects. Ghrelin/obestatin ratio positively correlated with weight, body mass index, waist, glucose, insulin, HOMA-IR, leptin, cholesterol, triglycerides, low density cholesterol and also with H. pylori antigen in the same group. CONCLUSIONS: It can be concluded that ghrelin, obestatin, and leptin are affected by presence of H. pylori seropositivity in obese subjects. The higher ghrelin levels and ghrelin/obestatin ratio with lowered obestatin could be considered as a gastro-protective effect against inflammation induced by H. pylori.
Entities:
Keywords:
H. pylori; ghrelin; leptin; obesity; obestatin
Authors: Verena M Santos; Anne Karoline P Brito; Aline T Amorim; Izadora R Souza; Maysa B Santos; Guilherme B Campos; Deborah C Dos Santos; Antônio Carlos R Braga Júnior; Jerusa M Santana; Djanilson B Santos; Marcio C Mancini; Jorge Timenetsky; Lucas M Marques Journal: Braz J Microbiol Date: 2022-03-11 Impact factor: 2.214