Takayuki Kaburagi1, Moriyuki Kiyoshima1, Takeshi Nawa2, Hideo Ichimura2, Takefumi Saito3, Kenji Hayashihara3, Hideyasu Yamada4, Hiroaki Satoh5, Takeo Endo6, Yoshihisa Inage6, Kazuhito Saito7, Masaharu Inagaki7, Nobuyuki Hizawa8, Yukio Sato8, Hiroichi Ishikawa9, Mitsuaki Sakai9, Koichi Kamiyama10, Norihiro Kikuchi11, Hiroyuki Nakamura12, Kinya Furukawa12, Takahide Kodama13, Takaaki Yamashita14, Akihiro Nomura15, Susumu Yoshida15. 1. Respiratory Center, Ibaraki Prefectural Central Hospital, Kasama, Japan. 2. Divisions of Respiratory Medicine and Thoracic Surgery, Hitachi General Hospital, Hitachi, Japan. 3. Division of Respiratory Medicine, Ibarakihigashi Hospital, Tokai, Japan. 4. Division of Respiratory Medicine, Hitachinaka General Hospital, Hitachinaka, Japan. 5. Division of Respiratory Medicine, Mito Kyodo General Hospital-Mito Medical Center, University of Tsukuba, Mito, Japan hirosato@md.tsukuba.ac.jp. 6. Divisions of Respiratory Medicine and Thoracic Surgery, Mito Medical Center, Mito, Japan. 7. Divisions of Respiratory Medicine and Thoracic Surgery, Tsuchiura Kyodo General Hospital, Tsuchiura, Japan. 8. Faculty of Clinical Medicine, University of Tsukuba, Tsukuba, Japan. 9. Divisions of Respiratory Medicine and Thoracic Surgery, Tsukuba Medical Center Hospital, Tsukuba, Japan. 10. Division of Thoracic Surgery, Tsukuba Memorial Hospital, Tsukuba, Japan. 11. Division of Respiratory Medicine, Kasumigaura Medical Center, Tsuchiura, Japan. 12. Divisions of Respiratory Medicine and Thoracic Surgery, Tokyo Medical University, Ibaraki Medical Center, Ami-machi, Japan. 13. Division of Respiratory Medicine, Ryugasaki Saiseikai Hospital, Ryugasaki, Japan. 14. Division of Respiratory Medicine, JA Toride Medical Center, Toride, Japan. 15. Divisions of Respiratory Medicine and Thoracic Surgery, Ibaraki Seinan Medical Center Hospital, Sakai-machi, Japan.
Abstract
AIM: To describe the prevalence and determinants of acquired epidermal growth factor receptor (EGFR) T790M gene mutation in a clinical practice setting. MATERIALS AND METHODS: We performed a retrospective chart review study between January 2013 and November 2017 across multiple institutes, covering a population of 3 million people. RESULTS: We reviewed the charts of 233 patients non-small cell lung cancer with EGFR mutations. Of them, 99 (42.5%) patients had acquired T790M mutations in EGFR. Patients ≥75 years old and patients with an exon 19 deletion had higher rates of acquired T790M mutation than did younger patients and those with an exon 21 L858R mutation. In 75 patients treated with afatinib, 34 (45.3%) patients had acquired T790M mutation. The sensitivity of T790M mutation detection was lower in plasma specimens than in biopsy specimens. CONCLUSION: This population-based study confirms previous studies and highlights potential determinants of acquired T790M mutation to be considered in clinical practice. Copyright
AIM: To describe the prevalence and determinants of acquired epidermal growth factor receptor (EGFR) T790M gene mutation in a clinical practice setting. MATERIALS AND METHODS: We performed a retrospective chart review study between January 2013 and November 2017 across multiple institutes, covering a population of 3 million people. RESULTS: We reviewed the charts of 233 patientsnon-small cell lung cancer with EGFR mutations. Of them, 99 (42.5%) patients had acquired T790M mutations in EGFR. Patients ≥75 years old and patients with an exon 19 deletion had higher rates of acquired T790M mutation than did younger patients and those with an exon 21 L858R mutation. In 75 patients treated with afatinib, 34 (45.3%) patients had acquired T790M mutation. The sensitivity of T790M mutation detection was lower in plasma specimens than in biopsy specimens. CONCLUSION: This population-based study confirms previous studies and highlights potential determinants of acquired T790M mutation to be considered in clinical practice. Copyright