| Literature DB >> 29714998 |
Mark L G Borst1, Cécile M J Ouairy1, Sander C Fokkema1, Alessandro Cecchi1, Jessica M C A Kerckhoffs1, Vincent L de Boer1, Peter J van den Boogaard1, Rutger F Bus1, Rijko Ebens1, Rob van der Hulst1, Joop Knol1, Rob Libbers1, Zhou M Lion1, Bart W Settels1, Ellen de Wever1, Khaled A Attia1, Piet-Jan Sinnema1, Jesse M de Gooijer1, Karen Harkema1, Marieke Hazewinkel1, Susan Snijder1, Kees Pouwer1.
Abstract
The design and synthesis of three novel polycyclic scaffolds containing sulfoximines are presented in this work, which exemplify that sulfoximines represent a real opportunity for the discovery of new drug candidates. Additionally, the structures present at least two points of diversification and contain a high level of sp3-character, hence being very interesting 3D scaffolds. The compounds synthesized were added to the compound collection of the European Lead Factory.Entities:
Keywords: European Lead Factory; bicyclic pyrazoles; bridged bicyclic structures; heteroatom-substituted spiro [3.3]heptanes; library production; sulfoximines
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Year: 2018 PMID： 29714998 DOI： 10.1021/acscombsci.7b00150
Source DB: PubMed Journal: ACS Comb Sci ISSN： 2156-8944 Impact factor: 3.784