Aisha S Dickerson1,2, Janice S Lee1, Channa Keshava1, Andrew Hotchkiss1,3, Amanda S Persad4. 1. Integrated Risk Information System, U.S. Environmental Protection Agency, 109 T.W. Alexander Dr. Research Triangle Park, Durham, NC, 27711, USA. 2. Oak Ridge Institute for Science and Education, Oak Ridge, TN, 37831, USA. 3. National Center for Environmental Assessment- RTP, U.S. Environmental Protection Agency, 109 T.W. Alexander Dr. Research Triangle Park, Durham, NC, 27711, USA. 4. Integrated Risk Information System, U.S. Environmental Protection Agency, 109 T.W. Alexander Dr. Research Triangle Park, Durham, NC, 27711, USA. Persad.Amanda@epa.gov.
Abstract
PURPOSE OF REVIEW: Urea has been utilized as a reductant in diesel fuels to lower emission of nitrogen oxides, igniting interest in probable human health hazards associated with exposure to exogenous urea. Here, we summarize and update key findings on potential health effects of exogenous urea, including carcinogenicity. RECENT FINDINGS: No definitive target organs for oral exposure were identified; however, results in animal studies suggest that the liver and kidney could be potential target organs of urea toxicity. The available human-subject literature suggests that the impact on lung function is minimal. Based on the literature on exogenous urea, we concluded that there was inadequate information to assess the carcinogenic potential of urea, or perform a quantitative assessment to derive reference values. Given the limited information on exogenous urea, additional research to address gaps for exogenous urea should include long-term cancer bioassays, two-generation reproductive toxicity studies, and mode-of-action investigations.
PURPOSE OF REVIEW: Urea has been utilized as a reductant in diesel fuels to lower emission of nitrogen oxides, igniting interest in probable human health hazards associated with exposure to exogenous urea. Here, we summarize and update key findings on potential health effects of exogenous urea, including carcinogenicity. RECENT FINDINGS: No definitive target organs for oral exposure were identified; however, results in animal studies suggest that the liver and kidney could be potential target organs of urea toxicity. The available human-subject literature suggests that the impact on lung function is minimal. Based on the literature on exogenous urea, we concluded that there was inadequate information to assess the carcinogenic potential of urea, or perform a quantitative assessment to derive reference values. Given the limited information on exogenous urea, additional research to address gaps for exogenous urea should include long-term cancer bioassays, two-generation reproductive toxicity studies, and mode-of-action investigations.
Entities:
Keywords:
Cancer assessment; Health effects; Human health assessment; IRIS; Integrated Risk Information System; Urea
Authors: W D Kloppenburg; B G Wolthers; F Stellaard; H Elzinga; T Tepper; P E de Jong; R M Huisman Journal: Clin Sci (Lond) Date: 1997-07 Impact factor: 6.124
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