Literature DB >> 29713804

[Deep learning to support therapy decisions for intravitreal injections].

P Prahs1, D Märker2, C Mayer3, H Helbig2.   

Abstract

Significant progress has been made in artificial intelligence and computer vision research in recent years. Machine learning methods excel in a wide variety of tasks where sufficient data are available. We describe the application of a deep convolutional neural network for the prediction of treatment indication with anti-vascular endothelial growth factor (VEGF) medications based on central retinal optical coherence tomography (OCT) scans. The neural network classifier was trained with OCT images acquired during routine treatment at the University of Regensburg over the years 2008-2016. In over 95% of the cases the treatment indication was accurately predicted based on a singular OCT B scan without human intervention. Despite promising classification the results of deep learning techniques, should always be controlled by the treating physician because false classification can never be excluded due to the probabilistic nature of the method.

Entities:  

Keywords:  Age-related macular degeneration; Anti-vascular endothelial growth factor; Artificial intelligence; Diabetic retinopathy; Optical coherence tomography

Mesh:

Substances:

Year:  2018        PMID: 29713804     DOI: 10.1007/s00347-018-0708-y

Source DB:  PubMed          Journal:  Ophthalmologe        ISSN: 0941-293X            Impact factor:   1.059


  12 in total

1.  The perceptron: a probabilistic model for information storage and organization in the brain.

Authors:  F ROSENBLATT
Journal:  Psychol Rev       Date:  1958-11       Impact factor: 8.934

2.  Interobserver variability for retreatment indications after Ranibizumab loading doses in neovascular age-related macular degeneration.

Authors:  Carsten Framme; Georgios Panagakis; Andreas Walter; Maria Andreea Gamulescu; Wolfgang Herrmann; Horst Helbig
Journal:  Acta Ophthalmol       Date:  2010-08-17       Impact factor: 3.761

3.  A fast learning algorithm for deep belief nets.

Authors:  Geoffrey E Hinton; Simon Osindero; Yee-Whye Teh
Journal:  Neural Comput       Date:  2006-07       Impact factor: 2.026

4.  Optical coherence tomography.

Authors:  D Huang; E A Swanson; C P Lin; J S Schuman; W G Stinson; W Chang; M R Hee; T Flotte; K Gregory; C A Puliafito
Journal:  Science       Date:  1991-11-22       Impact factor: 47.728

5.  Trends of Anti-Vascular Endothelial Growth Factor Use in Ophthalmology Among Privately Insured and Medicare Advantage Patients.

Authors:  Ravi Parikh; Joseph S Ross; Lindsey R Sangaralingham; Ron A Adelman; Nilay D Shah; Andrew J Barkmeier
Journal:  Ophthalmology       Date:  2016-11-24       Impact factor: 12.079

6.  Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs.

Authors:  Varun Gulshan; Lily Peng; Marc Coram; Martin C Stumpe; Derek Wu; Arunachalam Narayanaswamy; Subhashini Venugopalan; Kasumi Widner; Tom Madams; Jorge Cuadros; Ramasamy Kim; Rajiv Raman; Philip C Nelson; Jessica L Mega; Dale R Webster
Journal:  JAMA       Date:  2016-12-13       Impact factor: 56.272

7.  Automated detection of exudative age-related macular degeneration in spectral domain optical coherence tomography using deep learning.

Authors:  Maximilian Treder; Jost Lennart Lauermann; Nicole Eter
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2017-11-20       Impact factor: 3.117

Review 8.  State-of-the-art retinal optical coherence tomography.

Authors:  Wolfgang Drexler; James G Fujimoto
Journal:  Prog Retin Eye Res       Date:  2007-08-11       Impact factor: 21.198

9.  Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning.

Authors:  Daniel S Kermany; Michael Goldbaum; Wenjia Cai; Carolina C S Valentim; Huiying Liang; Sally L Baxter; Alex McKeown; Ge Yang; Xiaokang Wu; Fangbing Yan; Justin Dong; Made K Prasadha; Jacqueline Pei; Magdalene Y L Ting; Jie Zhu; Christina Li; Sierra Hewett; Jason Dong; Ian Ziyar; Alexander Shi; Runze Zhang; Lianghong Zheng; Rui Hou; William Shi; Xin Fu; Yaou Duan; Viet A N Huu; Cindy Wen; Edward D Zhang; Charlotte L Zhang; Oulan Li; Xiaobo Wang; Michael A Singer; Xiaodong Sun; Jie Xu; Ali Tafreshi; M Anthony Lewis; Huimin Xia; Kang Zhang
Journal:  Cell       Date:  2018-02-22       Impact factor: 41.582

10.  Interobserver agreement for the detection of optical coherence tomography features of neovascular age-related macular degeneration.

Authors:  Praveen J Patel; Andrew C Browning; Fred K Chen; Lyndon Da Cruz; Adnan Tufail
Journal:  Invest Ophthalmol Vis Sci       Date:  2009-06-24       Impact factor: 4.799

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