Literature DB >> 29713703

Unexpected arene ligand exchange results in the oxidation of an organoruthenium anticancer agent: the first X-ray structure of a protein-Ru(carbene) adduct.

Matthew P Sullivan1, Michél K Nieuwoudt2, Graham A Bowmaker3, Nelson Y S Lam3, Dianna Truong3, David C Goldstone4, Christian G Hartinger3.   

Abstract

The first X-ray structures of adducts formed between a RuII(N-heterocyclic carbene)(η6-p-cymene) compound and a protein are reported. Coordination to the protein induced the cleavage of the cymene ligand and EPR spectroscopy demonstrated the oxidation of the Ru centre.

Entities:  

Year:  2018        PMID： 29713703     DOI： 10.1039/c8cc02433b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  Ruthenium complexes show potent inhibition of AKR1C1, AKR1C2, and AKR1C3 enzymes and anti-proliferative action against chemoresistant ovarian cancer cell line.

Authors:  Jakob Kljun; Renata Pavlič; Eva Hafner; Tanja Lipec; Sara Moreno-Da Silva; Primož Tič; Iztok Turel; Tomaž Büdefeld; Jure Stojan; Tea Lanišnik Rižner
Journal:  Front Pharmacol       Date:  2022-08-11       Impact factor: 5.988

2.  Facile Arene Ligand Exchange in p-Cymene Ruthenium(II) Complexes of Tertiary P-Chiral Ferrocenyl Phosphines.

Authors:  John Popp; Schirin Hanf; Evamarie Hey-Hawkins
Journal:  ACS Omega       Date:  2019-12-19
  2 in total

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