| Literature DB >> 29712883 |
Karen Horsburgh1, Joanna M Wardlaw2, Tom van Agtmael3, Stuart M Allan4, Mike L J Ashford5, Philip M Bath6, Rosalind Brown7, Jason Berwick8, M Zameel Cader9, Roxana O Carare10, John B Davis11, Jessica Duncombe12, Tracy D Farr13, Jill H Fowler12, Jozien Goense14, Alessandra Granata15, Catherine N Hall16, Atticus H Hainsworth17, Adam Harvey3, Cheryl A Hawkes18, Anne Joutel19, Rajesh N Kalaria20, Patrick G Kehoe21, Catherine B Lawrence4, Andy Lockhart22, Seth Love23, Malcolm R Macleod7, I Mhairi Macrae14, Hugh S Markus15, Chris McCabe14, Barry W McColl24, Paul J Meakin25, Alyson Miller3, Maiken Nedergaard26, Michael O'Sullivan27, Terry J Quinn3, Rikesh Rajani19, Lisa M Saksida28, Colin Smith7, Kenneth J Smith29, Rhian M Touyz3, Rebecca C Trueman13, Tao Wang4, Anna Williams30, Steven C R Williams31, Lorraine M Work3.
Abstract
Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.Entities:
Keywords: cerebral vascular disease; dementia
Mesh：
Year: 2018 PMID： 29712883 PMCID： PMC6700732 DOI： 10.1042/CS20171620
Source DB: PubMed Journal: Clin Sci (Lond) ISSN： 0143-5221 Impact factor: 6.124