Literature DB >> 29712146

Design and Evolution of a Miniature Bcl-2 Binding Protein.

Jason W Chin1, Alanna Schepartz1.   

Abstract

A major challenge for chemical biologists lies in the design of potent and selective ligands for protein surfaces. Here a protein grafting and evolution strategy is used to discover highly potent and specific miniature protein ligands for human Bcl-2 and Bcl-XL . Miniature proteins could be used to dissect, modulate, or analyze a single protein function, irrespective of the other functions the protein may regulate within the proteome.
© 2001 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.

Entities:  

Keywords:  apoptosis ; protein design ; protein-protein interactions ; proteins

Year:  2001        PMID： 29712146     DOI： 10.1002/1521-3773(20011015)40:20<3806::AID-ANIE3806>3.0.CO;2-B

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  4 in total

Review 1.  Structural Details of BH3 Motifs and BH3-Mediated Interactions: an Updated Perspective.

Authors:  Valentina Sora; Elena Papaleo
Journal:  Front Mol Biosci       Date:  2022-05-24

2.  Facile synthesis of stapled, structurally reinforced peptide helices via a photoinduced intramolecular 1,3-dipolar cycloaddition reaction.

Authors:  Michael M Madden; Claudia I Rivera Vera; Wenjiao Song; Qing Lin
Journal:  Chem Commun (Camb)       Date:  2009-08-13       Impact factor: 6.222

3.  Exploring the binding of rationally engineered tandem-repeat proteins to E3 ubiquitin ligase Keap1.

Authors:  Sarah K Madden; Laura S Itzhaki
Journal:  Protein Eng Des Sel       Date:  2021-02-15       Impact factor: 1.650

4.  Rosetta FunFolDes - A general framework for the computational design of functional proteins.

Authors:  Jaume Bonet; Sarah Wehrle; Karen Schriever; Che Yang; Anne Billet; Fabian Sesterhenn; Andreas Scheck; Freyr Sverrisson; Barbora Veselkova; Sabrina Vollers; Roxanne Lourman; Mélanie Villard; Stéphane Rosset; Thomas Krey; Bruno E Correia
Journal:  PLoS Comput Biol       Date:  2018-11-19       Impact factor: 4.475
  4 in total

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