Literature DB >> 29712036

Total Synthesis of Dermostatin A.

Christopher J Sinz1, Scott D Rychnovsky1.   

Abstract

An oxo-hexaene macrolide antibiotic, dermostatin A has been synthesized. Key features of the synthesis include the application of cyanohydrin acetonide couplings for the synthesis of the polyol portion, and the convergent introduction of the polyene segment by means of a Stille coupling.
© 2001 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.

Entities:  

Keywords:  alkylation; asymmetric synthesis; cross-coupling; polyenes; total synthesis

Year:  2001        PMID： 29712036     DOI： 10.1002/1521-3773(20010903)40:17<3224::AID-ANIE3224>3.0.CO;2-D

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  2 in total

1.  Production, Detection, Extraction, and Quantification of Polyene Antibiotics.

Authors:  Eva G Barreales; Jesús F Aparicio
Journal:  Methods Mol Biol       Date:  2021

2.  Total synthesis of (+)-roxaticin via C-C bond forming transfer hydrogenation: a departure from stoichiometric chiral reagents, auxiliaries, and premetalated nucleophiles in polyketide construction.

Authors:  Soo Bong Han; Abbas Hassan; In Su Kim; Michael J Krische
Journal:  J Am Chem Soc       Date:  2010-11-10       Impact factor: 15.419
  2 in total

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