| Literature DB >> 29711503 |
E J Corey1, Weidong Li1, Tohru Nagamitsu1.
Abstract
A selective, irreversible inhibitor of proteasome function, lactacystin (1) is an important experimental tool in cell biology. An efficient and direct enantioselective synthesis of lactacystin proceeds via the intermediates shown below. This process allows for the first time easy access to analogues of lactacystin in which the isopropyl substituent is replaced by other lipophilic groups. PMB=p-methoxybenzyl. © 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.Entities:
Keywords: Enzyme inhibitors; Lactacystin; Lactones; Stereocontrol; Total synthesis
Year: 1998 PMID： 29711503 DOI： 10.1002/(SICI)1521-3773(19980703)37:12<1676::AID-ANIE1676>3.0.CO;2-T
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336