Literature DB >> 29711420

Highly Efficient Synthesis of Covalently Cross-Linked Peptide Helices by Ring-Closing Metathesis.

Helen E Blackwell1, Robert H Grubbs1.   

Abstract

Olefin metathesis has been successfully applied to the synthesis of macrocyclic helical peptides [Eq. (a)]. Carbon-carbon bond tethers between amino acid side chains were introduced by ring-closing metathesis. This macrocyclization protocol is a novel and mild procedure for introducing nonnative covalent cross-links into peptide helices. © 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.

Entities:  

Keywords:  Carbene complexes; Helical structures; Macrocycles; Metathesis; Peptides

Year:  1998        PMID： 29711420     DOI： 10.1002/(SICI)1521-3773(19981217)37:23<3281::AID-ANIE3281>3.0.CO;2-V

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  71 in total

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Authors:  Xin Qi; Tianbing Xia; Richard W Roberts
Journal:  Biochemistry       Date:  2010-07-13       Impact factor: 3.162

7.  Synthesis of cell-permeable stapled BH3 peptide-based Mcl-1 inhibitors containing simple aryl and vinylaryl cross-linkers.

Authors:  Avinash Muppidi; Kenichiro Doi; Carlo P Ramil; Hong-Gang Wang; Qing Lin
Journal:  Tetrahedron       Date:  2014-10-21       Impact factor: 2.457

Review 8.  Catalytic DNA: Scope, Applications, and Biochemistry of Deoxyribozymes.

Authors:  Scott K Silverman
Journal:  Trends Biochem Sci       Date:  2016-05-25       Impact factor: 13.807

9.  Rigid Peptide Macrocycles from On-Resin Glaser Stapling.

Authors:  Philip A Cistrone; Anthony P Silvestri; Jordi C J Hintzen; Philip E Dawson
Journal:  Chembiochem       Date:  2018-04-26       Impact factor: 3.164

10.  Template-constrained macrocyclic peptides prepared from native, unprotected precursors.

Authors:  Kenneth V Lawson; Tristan E Rose; Patrick G Harran
Journal:  Proc Natl Acad Sci U S A       Date:  2013-09-16       Impact factor: 11.205
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