| Literature DB >> 29711373 |
Scott McN Sieburth1, Thomas Nittoli1, Alfred M Mutahi1, Luxuan Guo1.
Abstract
Transition state analogues of the peptide hydrolysis intermediate can take the form of complex silanediols such as 1, which inhibits angiotensin-converting enzyme (ACE) at nanomolar concentrations. In contrast, earlier investigation of enzyme inhibition with simple silanediols and silanetriols showed them to be inactive. © 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.Entities:
Keywords: Angiotensin-converting enzyme; Enzyme inhibitors; Peptidomimetics; Silanols; Structure-activity relationships
Year: 1998 PMID： 29711373 DOI： 10.1002/(SICI)1521-3773(19980403)37:6<812::AID-ANIE812>3.0.CO;2-I
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336