Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone.

No heteroatom required! In many solid-phase syntheses, after the release from the polymer support a heteroatom (e.g. O, S, N) remains in the substrate as a residue of a linking protecting group. With polymer-bound tin reagents cleavage and cyclization of the substrate with C-C bond formation (see picture) can now be achieved by intramolecular Stille coupling. S=substrate. © 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.