| Literature DB >> 29711342 |
Lutz F Tietze1, Gyula Schneider2, János Wölfling2, Thomas Nöbel1, Christian Wulff1, Ingrid Schubert1, Angela Rübeling1.
Abstract
Numerous pharmacologically interesting compounds are available by the synthesis of hybrid natural products. Thus, for instance, the estrone-talaromycin hybrid 2, which is synthesized in a few steps from the estrone derivative 1 by a sequence in which a hetero-Diels-Alder reaction is the key step, exhibits notable cytotoxic activity. © 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.Entities:
Keywords: Antitumor agents; Cycloadditions; Mycotoxins; Spiro compounds; Steroids
Year: 1998 PMID： 29711342 DOI： 10.1002/(SICI)1521-3773(19981002)37:18<2469::AID-ANIE2469>3.0.CO;2-M
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336