| Literature DB >> 29711311 |
Sulan Yao1, Mogens Johannsen1, Rita G Hazell1, Karl Anker Jørgensen1.
Abstract
1 mol% of catalyst is sufficient: The hetero Diels-Alder reaction of α-imino esters 1 with activated conjugated dienes 2 (R=H, Me) needs only 1 mol% of a 2,2'-bis(diarylphosphanyl)-1,1'-binaphthyl (BINAP) copper(I) complex as the catalyst to generate the adducts 3 in good yields and with enantioselectivities up to 96%. The reaction can also be carried out on gram scale! Tos=H3 CC6 H4 SO2 ; TMS=Me3 Si. © 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.Entities:
Keywords: Asymmetric catalysis; Copper; Cycloadditions; Lewis acids; Synthetic methods
Year: 1998 PMID： 29711311 DOI： 10.1002/(SICI)1521-3773(19981204)37:22<3121::AID-ANIE3121>3.0.CO;2-J
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336