| Literature DB >> 29711292 |
Abstract
Four-component reactions: The Ugi reaction of four suitably functionalized carbohydrate derivatives (as a per-O-benzylated amine, an aldehyde, a carboxylic acid, and an isocyanide) allow the effective assembly of diverse compound libraries. The complex glycoconjugates formed can be deprotected (see the picture for an example), and the resulting glycomimetics are of high interest for screening purposes. © 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.Entities:
Keywords: Carbohydrates; Combinatorial chemistry; Glycoconjugates; Glycomimetics; Multicomponent reactions
Year: 1998 PMID： 29711292 DOI： 10.1002/(SICI)1521-3773(19981231)37:24<3436::AID-ANIE3436>3.0.CO;2-Z
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336