Literature DB >> 29711209

A Method for High-Throughput Screening of Enantioselective Catalysts.

Manfred T Reetz1, Michael H Becker1, Heinz-Werner Klein1, Detlef Stöckigt1.   

Abstract

About 1000 catalytic or stoichiometric asymmetric reactions of racemic compounds or prochiral substrates bearing enantiotopic groups can be analyzed per day. In this highly efficient method the enantioselectivity is determined by electrospray ionization mass spectrometry using isotopically labeled substrates. The picture shows the mass spectrum of the mixture obtained upon hydrolysis of 1 to afford the pseudo-enantiomeric products 2 and 3. © 1999 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.

Entities:  

Keywords:  Asymmetric catalysis; Combinatorial chemistry; Enzyme catalysis; High-throughput screening; Mass spectrometry

Year:  1999        PMID： 29711209     DOI： 10.1002/(SICI)1521-3773(19990614)38:12<1758::AID-ANIE1758>3.0.CO;2-8

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  8 in total

1.  "Cassette" in situ enzymatic screening identifies complementary chiral scaffolds for hydrolytic kinetic resolution across a range of epoxides.

Authors:  Sangeeta Dey; Douglas R Powell; Chunhua Hu; David B Berkowitz
Journal:  Angew Chem Int Ed Engl       Date:  2007       Impact factor: 15.336

Review 2.  Diversifying carotenoid biosynthetic pathways by directed evolution.

Authors:  Daisuke Umeno; Alexander V Tobias; Frances H Arnold
Journal:  Microbiol Mol Biol Rev       Date:  2005-03       Impact factor: 11.056

3.  Chiral recognition in gas-phase cyclodextrin: amino acid complexes--is the three point interaction still valid in the gas phase?

Authors:  S Ahn; J Ramirez; G Grigorean; C B Lebrilla
Journal:  J Am Soc Mass Spectrom       Date:  2001-03       Impact factor: 3.262

4.  Substrate multiplexed protein engineering facilitates promiscuous biocatalytic synthesis.

Authors:  Allwin D McDonald; Peyton M Higgins; Andrew R Buller
Journal:  Nat Commun       Date:  2022-09-06       Impact factor: 17.694

5.  Quantification of Biocatalytic Transformations by Single Microbial Cells Enabled by Tailored Integration of Droplet Microfluidics and Mass Spectrometry.

Authors:  Konstantin Wink; Marie van der Loh; Nora Hartner; Matthias Polack; Christian Dusny; Andreas Schmid; Detlev Belder
Journal:  Angew Chem Int Ed Engl       Date:  2022-05-31       Impact factor: 16.823

6.  Rapid organocatalytic chirality analysis of amines, amino acids, alcohols, amino alcohols and diols with achiral iso(thio)cyanate probes.

Authors:  Eryn Nelson; Jeffrey S S K Formen; C Wolf
Journal:  Chem Sci       Date:  2021-05-25       Impact factor: 9.825

7.  Biocatalyst Screening with a Twist: Application of Oxygen Sensors Integrated in Microchannels for Screening Whole Cell Biocatalyst Variants.

Authors:  Ana C Fernandes; Julia M Halder; Bettina M Nestl; Bernhard Hauer; Krist V Gernaey; Ulrich Krühne
Journal:  Bioengineering (Basel)       Date:  2018-04-09

8.  Optically Pure Aziridin-2-yl Methanols as Readily Available 1H NMR Sensors for Enantiodiscrimination of α-Racemic Carboxylic Acids Containing Tertiary or Quaternary Stereogenic Centers.

Authors:  Martyna Malinowska; Szymon Jarzyński; Adam Pieczonka; Michał Rachwalski; Stanisław Leśniak; Anna Zawisza
Journal:  J Org Chem       Date:  2020-09-02       Impact factor: 4.354
  8 in total

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