| Literature DB >> 29711149 |
Maurice Petitou1, Philippe Duchaussoy1, Pierre-A Driguez1, Guy Jaurand1, Jean-P Hérault1, Jean-C Lormeau1, Constant A A van Boeckel2, Jean-M Herbert1.
Abstract
A single disaccharide building block is required to obtain synthetic carbohydrates that reproduce the anticoagulant activity of heparin and inhibit thrombin (n>6) and/or factor Xa (n≥2; see reaction scheme). Thus, there is evidence that heparin fragments with at least 15 saccharide units are required for thrombin inhibition. Lev=levulinoyl. © 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.Entities:
Keywords: Drug research; Enzyme inhibitors; Heparin; Oligosaccharides; Serine proteinases
Year: 1998 PMID： 29711149 DOI： 10.1002/(SICI)1521-3773(19981116)37:21<3009::AID-ANIE3009>3.0.CO;2-F
Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336