Cooperative Hydrogen Bonding and Enzyme Catalysis.

An important contribution to enzyme catalysis may be made by cooperative effects-which are induced by the interactions of a negatively charged ligand L with peptide hydrogen bond networks-through stabilization of charge formation along the reaction pathway. This has been found from density functional calculations on model systems for peptide hydrogen bond networks (an example is shown in the picture). © 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.