Literature DB >> 29711104

Expanding the Potential of DNA for Binding and Catalysis: Highly Functionalized dUTP Derivatives That Are Substrates for Thermostable DNA Polymerases.

Kandasamy Sakthivel1, Carlos F Barbas Iii1.   

Abstract

The discovery of a simple structural motif allows for the enzymatic synthesis by polymerase chain reactions (PCR) of modified DNA (see reaction scheme) bearing side chains similar or even identical to those of several amino acids. Libraries of DNA functionalized with both cationic and anionic groups may now be readily prepared. R=I, HgCl; X=functional group. © 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.

Entities:  

Keywords:  Aptamers; Combinatorial chemistry; DNA-enzymes; In vitro selection; Nucleotides

Year:  1998        PMID： 29711104     DOI： 10.1002/(SICI)1521-3773(19981102)37:20<2872::AID-ANIE2872>3.0.CO;2-5

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  14 in total

1.  Site-specifically arraying small molecules or proteins on DNA using an expanded genetic alphabet.

Authors:  Zhengtao Li; Thomas Lavergne; Denis A Malyshev; Jörg Zimmermann; Ramkrishna Adhikary; Kirandeep Dhami; Phillip Ordoukhanian; Zhelin Sun; Jie Xiang; Floyd E Romesberg
Journal:  Chemistry       Date:  2013-09-11       Impact factor: 5.236

2.  Enhancing the catalytic repertoire of nucleic acids. II. Simultaneous incorporation of amino and imidazolyl functionalities by two modified triphosphates during PCR.

Authors:  T Gourlain; A Sidorov; N Mignet; S J Thorpe; S E Lee; J A Grasby; D M Williams
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

3.  m5C RNA and m5C DNA methyl transferases use different cysteine residues as catalysts.

Authors:  Y Liu; D V Santi
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-18       Impact factor: 11.205

4.  Substrate specificity and kinetic framework of a DNAzyme with an expanded chemical repertoire: a putative RNaseA mimic that catalyzes RNA hydrolysis independent of a divalent metal cation.

Authors:  Richard Ting; Jason M Thomas; Leonard Lermer; David M Perrin
Journal:  Nucleic Acids Res       Date:  2004-12-29       Impact factor: 16.971

5.  Systematic characterization of 2'-deoxynucleoside- 5'-triphosphate analogs as substrates for DNA polymerases by polymerase chain reaction and kinetic studies on enzymatic production of modified DNA.

Authors:  Masayasu Kuwahara; Jun-ichi Nagashima; Masatoshi Hasegawa; Takehiro Tamura; Rina Kitagata; Kazuo Hanawa; Shin-ichi Hososhima; Toshiyuki Kasamatsu; Hiroaki Ozaki; Hiroaki Sawai
Journal:  Nucleic Acids Res       Date:  2006-09-29       Impact factor: 16.971

6.  Mechanical properties of DNA-like polymers.

Authors:  Justin P Peters; Shweta P Yelgaonkar; Seergazhi G Srivatsan; Yitzhak Tor; L James Maher
Journal:  Nucleic Acids Res       Date:  2013-09-05       Impact factor: 16.971

Review 7.  Molecular evolution of functional nucleic acids with chemical modifications.

Authors:  Masayasu Kuwahara; Naoki Sugimoto
Journal:  Molecules       Date:  2010-08-09       Impact factor: 4.411

8.  Sequence-specific cleavage of RNA in the absence of divalent metal ions by a DNAzyme incorporating imidazolyl and amino functionalities.

Authors:  Alexander V Sidorov; Jane A Grasby; David M Williams
Journal:  Nucleic Acids Res       Date:  2004-03-05       Impact factor: 16.971

9.  DNA modification under mild conditions by Suzuki-Miyaura cross-coupling for the generation of functional probes.

Authors:  Lukas Lercher; Joanna F McGouran; Benedikt M Kessler; Christopher J Schofield; Benjamin G Davis
Journal:  Angew Chem Int Ed Engl       Date:  2013-08-13       Impact factor: 15.336

Review 10.  Nucleoside triphosphates--building blocks for the modification of nucleic acids.

Authors:  Marcel Hollenstein
Journal:  Molecules       Date:  2012-11-15       Impact factor: 4.411
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