An Enzyme-Labile Linker Group for Organic Syntheses on Solid Supports.

Lipases and esterases can be used to fragment the 4-acetyloxybenzyloxy group used as a linker for organic synthesis on solid supports. (A support-bound compound is shown on the right; the enzyme-labile bond is marked with an arrow.) This enzyme-initiated fragmentation proceeds under very mild conditions (pH 6-7, room temperature), and the compounds of interest (amines, alcohols, carboxylic acids; X=NH, O, CR2 ) constructed by combinatorial chemistry can be released with complete selectivity. © 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.