Literature DB >> 2970975

A highly potent and selective H3 agonist relaxes rabbit middle cerebral artery, in vitro.

L Ea-Kim1, N Oudart.   

Abstract

An H3-agonist, R alpha methylhistamine strongly relaxed isolated and perfused rabbit middle cerebral artery precontracted with K+. This vasodilatation was not antagonized by either mepyramine or cimetidine but was competitively antagonized by an H3-antagonist, a mixture of impromidine and cimetidine. Histamine activated the H3-sites in this artery since its concentration-response curve (obtained with mepyramine and cimetidine) was parallel to that of R alpha methylhistamine. Our data indicate that H3-sites could exist in the rabbit cerebral artery.

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Year:  1988        PMID： 2970975     DOI： 10.1016/0014-2999(88)90026-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

Review 1.  Plenary lecture. A third histamine receptor subtype: characterisation, localisation and functions of the H3-receptor.

Authors:  J C Schwartz; J M Arrang; M Garbarg; H Pollard
Journal:  Agents Actions       Date:  1990-04

2.  Histamine H3-receptor activation inhibits acetylcholine release from the guinea pig myenteric plexus.

Authors:  E Poli; H Stark; G Bertaccini
Journal:  Agents Actions       Date:  1991-05

3.  Identification of endothelial H1, vascular H2 and cardiac presynaptic H3 receptors in the pithed rat.

Authors:  B Malinowska; E Schlicker
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-01       Impact factor: 3.000

4.  Characterization of the histamine receptors in the guinea-pig lung: evidence for relaxant histamine H3 receptors in the trachea.

Authors:  L O Cardell; L Edvinsson
Journal:  Br J Pharmacol       Date:  1994-02       Impact factor: 8.739

5.  Cardiovascular effects of selective agonists and antagonists of histamine H3 receptors in the anaesthetized rat.

Authors:  G Coruzzi; E Gambarelli; G Bertaccini; H Timmerman
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-06       Impact factor: 3.000

6.  Histamine H3-receptor activation augments voltage-dependent Ca2+ current via GTP hydrolysis in rabbit saphenous artery.

Authors:  M Oike; K Kitamura; H Kuriyama
Journal:  J Physiol       Date:  1992-03       Impact factor: 5.182

7.  Endothelium-dependent relaxation of rabbit middle cerebral artery to a histamine H3-agonist is reduced by inhibitors of nitric oxide and prostacyclin synthesis.

Authors:  L Ea Kim; J Javellaud; N Oudart
Journal:  Br J Pharmacol       Date:  1992-01       Impact factor: 8.739

8.  H3-receptor regulation of vascular gastrin and somatostatin releases by the isolated rat stomach.

Authors:  A Bado; L Moizo; J P Laigneau; J Delwaide; M J Lewin
Journal:  Yale J Biol Med       Date:  1994 May-Aug
  8 in total

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