| Literature DB >> 29709516 |
Xiaoxun Wang1, Xiaofang Che1, Chang Liu1, Yibo Fan1, Ming Bai1, Kezuo Hou1, Xiaonan Shi1, Xiaojie Zhang1, Bofang Liu1, Chunlei Zheng1, Yunpeng Liu2, Xiujuan Qu3.
Abstract
Cancer-associated fibroblasts (CAFs) are major components of the tumor stroma and regulators of tumor progression. However, the molecular mechanism by which CAFs promote gastric cancer progression should be further explored. In our study, we found that interleukin-11 (IL-11) secretion was significantly increased when CAFs were co-cultured with gastric cancer cells. Co-culture system-derived IL-11 promoted the migration and invasion of gastric cancer cells, whereas the increase of migration and invasion was attenuated by a neutralizing antibody of IL-11 or inhibition of JAK/STAT3 and MAPK/ERK pathways with specific inhibitors. Taken together, these results revealed that CAFs play a significant role in the gastric cancer progression in the tumor microenvironment through IL-11-STAT3/ERK signaling by upregulating MUC1. Also, IL-11 targeted therapy can achieve an effective treatment against gastric cancer indirectly by exerting their action on stromal fibroblasts.Entities:
Keywords: CAFs; IL-11; Invasion; MUC1; Migration
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Year: 2018 PMID： 29709516 DOI： 10.1016/j.yexcr.2018.04.028
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905