Eric A Dik1, Norbertus A Ipenburg2, Peter A Kessler3, Robert J J van Es2, Stefan M Willems4. 1. Department of Cranio-Maxillofacial Surgery, Maastricht University Medical Centre, Maastricht, P. Debyelaan 25, PO Box 5800, NL 6202 AZ, Maastricht, The Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands. Electronic address: e.dik@radboudumc.nl. 2. Department of Head and Neck Surgical Oncology, Utrecht Cancer Center, University Medical Center Utrecht, Heidelberglaan 100, G.05.129, PO Box 85500, NL 3508 GA, Utrecht, The Netherlands. 3. Department of Cranio-Maxillofacial Surgery, Maastricht University Medical Centre, Maastricht, P. Debyelaan 25, PO Box 5800, NL 6202 AZ, Maastricht, The Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre, Maastricht, The Netherlands. 4. Department of Pathology University Medical Center Utrecht, Heidelberglaan 100, H4.4129, PO Box 85500, NL 3508 GA, Utrecht, The Netherlands.
Abstract
INTRODUCTION: In oral squamous cell carcinoma (OSCC) the differentiation grade of the tumor is determined on the biopsy and the resection specimen. The relation between tumor grade, nodal metastasis and survival is debatable. The aims of this study were to determine the correlation between differentiation grade of the biopsy and the resection specimen. Furthermore, we wanted to correlate tumor differentiation grade with nodal stage and survival. PATIENTS AND METHODS: One-hundred and forty-five patients with OSCC staged as T1-2, N0 of the tongue, floor of mouth or cheek with primary resection of the tumor were examined. Biopsy and resection specimen were histologically re-assessed with regard to differentiation grade, as well as infiltrative, peri-neural and vascular invasive growth. RESULTS: This study showed a poor correlation between differentiation grade in the incisional biopsy and the resection specimen of the same tumor. No significant relation between differentiation grade of the resection specimen and nodal involvement, as well as overall and disease-specific survival was found. CONCLUSION: In early OSCC the differentiation grade determined by biopsy is of little predictive value for the grading of the resection specimen. Poor differentiation grade could not be related to the presence of nodal metastasis or survival and seems not to have any prognostic value concerning outcome. Treatment planning must be related to these findings.
INTRODUCTION: In oral squamous cell carcinoma (OSCC) the differentiation grade of the tumor is determined on the biopsy and the resection specimen. The relation between tumor grade, nodal metastasis and survival is debatable. The aims of this study were to determine the correlation between differentiation grade of the biopsy and the resection specimen. Furthermore, we wanted to correlate tumor differentiation grade with nodal stage and survival. PATIENTS AND METHODS: One-hundred and forty-five patients with OSCC staged as T1-2, N0 of the tongue, floor of mouth or cheek with primary resection of the tumor were examined. Biopsy and resection specimen were histologically re-assessed with regard to differentiation grade, as well as infiltrative, peri-neural and vascular invasive growth. RESULTS: This study showed a poor correlation between differentiation grade in the incisional biopsy and the resection specimen of the same tumor. No significant relation between differentiation grade of the resection specimen and nodal involvement, as well as overall and disease-specific survival was found. CONCLUSION: In early OSCC the differentiation grade determined by biopsy is of little predictive value for the grading of the resection specimen. Poor differentiation grade could not be related to the presence of nodal metastasis or survival and seems not to have any prognostic value concerning outcome. Treatment planning must be related to these findings.
Authors: Wilko Weichert; Melanie Boxberg; Moritz Jesinghaus; Katja Steiger; Fabian Stögbauer; Bernhard Haller; Andreas Kolk; Ulrich Straßen; Anja Pickhard; Markus Wirth; Miguel Silva; Jan Budczies; Aaron Becker von Rose; Björn Konukiewitz; Peer Kuhn; Konrad Klinghammer; Hendrik Dapper; Stefan Münch; Stephanie E Combs Journal: Br J Cancer Date: 2020-01-15 Impact factor: 7.640