Dominique Maciejewski1,2, Manon Hillegers1, Brenda Penninx2. 1. Department of Child and Adolescent Psychology and Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands. 2. Department of Psychiatry, Amsterdam Public Health Research Institute, VU Medical Center, Amsterdam, The Netherlands.
Abstract
PURPOSE OF REVIEW: Offspring of parents with mood disorders (major depressive and bipolar disorder) are at increased risk for developing mood disorders. In this review, an overview regarding the intergenerational transmission of mood disorders, screening, and preventive intervention is given for this vulnerable group. RECENT FINDINGS: Offspring of parents with depression have a 40% chance of developing a depression, whereas offspring of parents with bipolar disorder have a 10% chance of developing a bipolar disorder by adulthood. Studies into the intergenerational transmission of mood disorders show that children of parents with mood disorders have increased biological dysregulation and neuropsychosocial impairments. Although there is a clear need for early identification of those at the highest risk, there are few systematic attempts in mental health care to screen children of parents with mood disorders. Lastly, preventive interventions seem to be effective in reducing depressive symptoms of children of parents with depression; however, those effects are small and short-lived. SUMMARY: Offspring of parents with mood disorders constitute a vulnerable group at high risk of mood disorders. More research needs to be conducted regarding mechanisms of the intergenerational transmission. Moreover, screening and preventive interventions for these offspring should be systematically evaluated and implemented.
PURPOSE OF REVIEW: Offspring of parents with mood disorders (major depressive and bipolar disorder) are at increased risk for developing mood disorders. In this review, an overview regarding the intergenerational transmission of mood disorders, screening, and preventive intervention is given for this vulnerable group. RECENT FINDINGS: Offspring of parents with depression have a 40% chance of developing a depression, whereas offspring of parents with bipolar disorder have a 10% chance of developing a bipolar disorder by adulthood. Studies into the intergenerational transmission of mood disorders show that children of parents with mood disorders have increased biological dysregulation and neuropsychosocial impairments. Although there is a clear need for early identification of those at the highest risk, there are few systematic attempts in mental health care to screen children of parents with mood disorders. Lastly, preventive interventions seem to be effective in reducing depressive symptoms of children of parents with depression; however, those effects are small and short-lived. SUMMARY: Offspring of parents with mood disorders constitute a vulnerable group at high risk of mood disorders. More research needs to be conducted regarding mechanisms of the intergenerational transmission. Moreover, screening and preventive interventions for these offspring should be systematically evaluated and implemented.
Authors: Jasmijn M de Lijster; Michiel A van den Dries; Jan van der Ende; Elisabeth M W J Utens; Vincent W Jaddoe; Gwendolyn C Dieleman; Manon H J Hillegers; Henning Tiemeier; Jeroen S Legerstee Journal: J Abnorm Child Psychol Date: 2019-11
Authors: Ralph Kupka; Anne Duffy; Jan Scott; Jorge Almeida; Vicent Balanzá-Martínez; Boris Birmaher; David J Bond; Elisa Brietzke; Ines Chendo; Benicio N Frey; Iria Grande; Danella Hafeman; Tomas Hajek; Manon Hillegers; Marcia Kauer-Sant'Anna; Rodrigo B Mansur; Afra van der Markt; Robert Post; Mauricio Tohen; Hailey Tremain; Gustavo Vazquez; Eduard Vieta; Lakshmi N Yatham; Michael Berk; Martin Alda; Flávio Kapczinski Journal: Bipolar Disord Date: 2021-07-23 Impact factor: 5.345
Authors: Hanna Christiansen; Annette Bauer; Batool Fatima; Melinda Goodyear; Ingunn Olea Lund; Ingrid Zechmeister-Koss; Jean Lillian Paul Journal: Front Psychiatry Date: 2019-04-17 Impact factor: 4.157
Authors: Eleonore D van Sprang; Dominique F Maciejewski; Yuri Milaneschi; Bernet M Elzinga; Aartjan T F Beekman; Catharina A Hartman; Albert M van Hemert; Brenda W J H Penninx Journal: Psychol Med Date: 2020-07-06 Impact factor: 7.723