Marwa Kaisey1, Nancy Sicotte1, Barbara Giesser1. 1. Department of Neurology (MK, MS), Cedars-Sinai Medical Center, Los Angeles, CA; and Department of Neurology (BG), University of California, Los Angeles.
Abstract
PURPOSE OF REVIEW: Multiple sclerosis (MS) disease activity and symptoms are tied to hormonal changes. This review explains the current standard of care in MS at various stages of a woman's reproductive life and helps neurologists answer patients' most common questions surrounding MS care and fertility, pregnancy, and menopause. RECENT FINDINGS: Recent work has focused on MS risk and exacerbation with variables related to reproductive health. Management of disease-modifying therapies prenatally and postnatally is also a focus. SUMMARY: This review is a concise, practical guide for general neurologists caring for women with MS. MS is a disease that requires adaptation of management as a woman moves through reproductive stages. With proper planning and management, pregnancy is safe for women with MS. We describe the current standard of care based on trials, when available, and on expert opinion.
PURPOSE OF REVIEW: Multiple sclerosis (MS) disease activity and symptoms are tied to hormonal changes. This review explains the current standard of care in MS at various stages of a woman's reproductive life and helps neurologists answer patients' most common questions surrounding MS care and fertility, pregnancy, and menopause. RECENT FINDINGS: Recent work has focused on MS risk and exacerbation with variables related to reproductive health. Management of disease-modifying therapies prenatally and postnatally is also a focus. SUMMARY: This review is a concise, practical guide for general neurologists caring for women with MS. MS is a disease that requires adaptation of management as a woman moves through reproductive stages. With proper planning and management, pregnancy is safe for women with MS. We describe the current standard of care based on trials, when available, and on expert opinion.
Authors: A-L Ponsonby; R M Lucas; I A van der Mei; K Dear; P C Valery; M P Pender; B V Taylor; T J Kilpatrick; A Coulthard; C Chapman; D Williams; A J McMichael; T Dwyer Journal: Neurology Date: 2012-03-07 Impact factor: 9.910