Literature DB >> 2970816

Bronchoconstriction by nebulized metabisulfite solutions (SO2) and its modification by ipratropium bromide.

J P Seale1, D M Temple, C M Tennant.   

Abstract

A nebulized solution of sodium metabisulfite (MBS) induced bronchoconstriction in nine subjects with asthma. An anticholinergic drug, ipratropium bromide (IPRA), in doses (500 to 700 micrograms) which were found to inhibit methacholine-induced bronchoconstriction, protected three of the nine subjects against nebulized MBS. These results suggest that both cholinergic and non-cholinergic reflex mechanisms are involved in MBS-induced bronchoconstriction.

Entities:  

Mesh：

Substances：

Year:  1988        PMID： 2970816

Source DB:  PubMed          Journal:  Ann Allergy        ISSN： 0003-4738


  5 in total

1.  Role of sulfite additives in wine induced asthma: single dose and cumulative dose studies.

Authors:  H Vally; P J Thompson
Journal:  Thorax       Date:  2001-10       Impact factor: 9.139

2.  Pharmacological modulation of inhaled sodium metabisulphite-induced airway microvascular leakage and bronchoconstriction in the guinea-pig.

Authors:  T Sakamoto; W Elwood; P J Barnes; K F Chung
Journal:  Br J Pharmacol       Date:  1992-10       Impact factor: 8.739

3.  Inhibition of inhaled metabisulphite-induced bronchoconstriction by inhaled frusemide and ipratropium bromide.

Authors:  G J Bellingan; C M Dixon; P W Ind
Journal:  Br J Clin Pharmacol       Date:  1992-07       Impact factor: 4.335

4.  Effects of sodium metabisulphite on guinea pig contractile airway smooth muscle responses in vitro.

Authors:  J Sun; T Sakamoto; K F Chung
Journal:  Thorax       Date:  1995-08       Impact factor: 9.139

5.  Effect of sodium metabisulphite on bronchial blood flow in conscious sheep: pharmacological modulation.

Authors:  G M Nichol; G H Parsons; K F Chung
Journal:  Br J Pharmacol       Date:  1994-03       Impact factor: 8.739
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.