OBJECTIVES: The aim of the study was to comparatively evaluate the psychological and functional effect of different primary treatments in patients with prostate cancer. METHODS AND MATERIALS: We conducted a single-center prospective non randomized study in a real-life setting using functional and psychological questionnaires in prostate cancer cases submitted to radical prostatectomy, external radiotherapy, or active surveillance. Totally, 220 cases were evaluated at baseline and during the follow-up at 1-, 3-, 6-, and 12-month interval after therapy. Patients self-completed questionnaires on urinary symptoms and incontinence, erectile and bowel function, psychological distress (PD), anxiety, and depression. RESULTS: Several significant differences among the three groups of treatment were found regarding the total score of the functional questionnaires. Regarding PD, cases submitted to radical prostatectomy showed stable scores during all the 12 months of follow-up whereas cases submitted to radiotherapy showed a rapid significant worsening of scores at 1-month interval and persistent also at 6- and 12-month interval. Cases submitted to active surveillance showed a slight and slow worsening of scores only at 12-month interval. PD and depression resulted to be more associated with urinary symptoms than sexual function worsening whereas anxiety resulted to be associated either with urinary symptoms or sexual function worsening. CONCLUSIONS: The results of our comparative and prospective analysis could be used to better inform treatment decision-making. Patients and their teams might wish to know how functional and psychological aspects may differently be influenced by treatment choice.
OBJECTIVES: The aim of the study was to comparatively evaluate the psychological and functional effect of different primary treatments in patients with prostate cancer. METHODS AND MATERIALS: We conducted a single-center prospective non randomized study in a real-life setting using functional and psychological questionnaires in prostate cancer cases submitted to radical prostatectomy, external radiotherapy, or active surveillance. Totally, 220 cases were evaluated at baseline and during the follow-up at 1-, 3-, 6-, and 12-month interval after therapy. Patients self-completed questionnaires on urinary symptoms and incontinence, erectile and bowel function, psychological distress (PD), anxiety, and depression. RESULTS: Several significant differences among the three groups of treatment were found regarding the total score of the functional questionnaires. Regarding PD, cases submitted to radical prostatectomy showed stable scores during all the 12 months of follow-up whereas cases submitted to radiotherapy showed a rapid significant worsening of scores at 1-month interval and persistent also at 6- and 12-month interval. Cases submitted to active surveillance showed a slight and slow worsening of scores only at 12-month interval. PD and depression resulted to be more associated with urinary symptoms than sexual function worsening whereas anxiety resulted to be associated either with urinary symptoms or sexual function worsening. CONCLUSIONS: The results of our comparative and prospective analysis could be used to better inform treatment decision-making. Patients and their teams might wish to know how functional and psychological aspects may differently be influenced by treatment choice.
Authors: Amy Y Zhang; Stephen Ganocy; Alex Z Fu; Denise Kresevic; Lee Ponsky; Gerald Strauss; Donald R Bodner; Hui Zhu Journal: Support Care Cancer Date: 2019-03-22 Impact factor: 3.603
Authors: Konstantina G Yiannopoulou; Aikaterini I Anastasiou; Konstantinos Kontoangelos; Charalambos Papageorgiou; Ioannis P Anastasiou Journal: Curr Urol Date: 2020-12-18
Authors: Stefano Salciccia; Davide Rosati; Pietro Viscuso; Vittorio Canale; Emiliano Scarrone; Marco Frisenda; Roberta Catuzzi; Martina Moriconi; Vincenzo Asero; Stefano Signore; Mauro De Dominicis; Paolo Emiliozzi; Antonio Carbone; Antonio Luigi Pastore; Andrea Fuschi; Giovanni Battista Di Pierro; Alessandro Gentilucci; Susanna Cattarino; Gianna Mariotti; Gian Maria Busetto; Matteo Ferro; Ettore De Berardinis; Gian Piero Ricciuti; Valeria Panebianco; Fabio Massimo Magliocca; Francesco Del Giudice; Martina Maggi; Alessandro Sciarra Journal: Cent European J Urol Date: 2021-11-29
Authors: Alessandro Sciarra; Stefano Salciccia; Martina Maggi; Francesco Del Giudice; Gian Maria Busetto; Daniela Musio; Antonio Ciardi; Carlo Catalano; Enrico Cortesi; Valeria Panebianco Journal: Prostate Cancer Prostatic Dis Date: 2020-05-18 Impact factor: 5.455