Yaqin Wang1, Jianping Xiong2, Meng Niu1, Weiyu Xu2, Ke Xu3, Hongshan Zhong4. 1. Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China. 2. Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing 100730, China. 3. Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.. Electronic address: kexu@vip.sina.com. 4. Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.. Electronic address: hszhong@cmu.edu.cn.
Abstract
BACKGROUND: Several studies have reported that hepatitis B virus (HBV) infection affects the risk of coronary heart disease. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to better understand it. METHODS: Relevant studies published before October 2017 were identified by searching PubMed, EMBASE, and ISI Web of Science. The relationships between HBV and the risk of coronary heart disease were assessed using Relative risk (RR) values and the corresponding 95% confidence intervals (CIs). We used the random effects model proposed by DerSimonian and Laird to quantify the relationship. RESULTS: Nine articles, including 65,058 HBV-infected patients and 534,998 uninfected controls, were included in the meta-analysis. The present study does not support that HBV infection is associated with the risk of coronary heart disease (RR = 0.99, CI = 0.76-1.22; I2 = 68.9%). Sensitivity analysis and 'trim and fill' method yielded similar results. No evidence of publication bias was observed. CONCLUSIONS: HBV infection does not increase the risk of coronary heart disease. The associations were not significant both in cohort studies and in case-control studies.
BACKGROUND: Several studies have reported that hepatitis B virus (HBV) infection affects the risk of coronary heart disease. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to better understand it. METHODS: Relevant studies published before October 2017 were identified by searching PubMed, EMBASE, and ISI Web of Science. The relationships between HBV and the risk of coronary heart disease were assessed using Relative risk (RR) values and the corresponding 95% confidence intervals (CIs). We used the random effects model proposed by DerSimonian and Laird to quantify the relationship. RESULTS: Nine articles, including 65,058 HBV-infectedpatients and 534,998 uninfected controls, were included in the meta-analysis. The present study does not support that HBV infection is associated with the risk of coronary heart disease (RR = 0.99, CI = 0.76-1.22; I2 = 68.9%). Sensitivity analysis and 'trim and fill' method yielded similar results. No evidence of publication bias was observed. CONCLUSIONS:HBV infection does not increase the risk of coronary heart disease. The associations were not significant both in cohort studies and in case-control studies.
Authors: Seogsong Jeong; Yun Hwan Oh; Seulggie Choi; Jooyoung Chang; Sung Min Kim; Joung Sik Son; Gyeongsil Lee; Won Kim; Sang Min Park Journal: Gut Liver Date: 2021-11-03 Impact factor: 4.321