Emilie Langlais1, Nicolas Nesseler2, Estelle Le Pabic3, Denis Frasca4, Yoann Launey5, Philippe Seguin6. 1. CHU de Rennes, Service d'Anesthésie Réanimation 1, 2 rue Henri Le Guilloux, Rennes 35000, France. Electronic address: emilielanglais@wanadoo.fr. 2. CHU de Rennes, Service d'Anesthésie Réanimation 1, 2 rue Henri Le Guilloux, Rennes 35000, France; Inserm, UMR 1214 NuMeCan, Rennes 35000, France; Inserm 1414, Centre d'Investigation Clinique, Rennes 35000, France; Université Rennes 1, Rennes 35000, France. Electronic address: Nicolas.nesseler@chu-rennes.fr. 3. Inserm 1414, Centre d'Investigation Clinique, Rennes 35000, France. Electronic address: estelle.le.pabic@chu-rennes.fr. 4. CHU de Poitiers, Inserm, UMR 1246, SPHERE, Universités de Nantes et Tours, France. Electronic address: denis.frasca@chu-poitiers.fr. 5. CHU de Rennes, Service d'Anesthésie Réanimation 1, 2 rue Henri Le Guilloux, Rennes 35000, France; Inserm, UMR 1214 NuMeCan, Rennes 35000, France; Université Rennes 1, Rennes 35000, France. Electronic address: yoann.launey@chu-rennes.fr. 6. CHU de Rennes, Service d'Anesthésie Réanimation 1, 2 rue Henri Le Guilloux, Rennes 35000, France; Inserm, UMR 1214 NuMeCan, Rennes 35000, France; Inserm 1414, Centre d'Investigation Clinique, Rennes 35000, France; Université Rennes 1, Rennes 35000, France. Electronic address: philippe.seguin@chu-rennes.fr.
Abstract
PURPOSE: To determine whether the addition of the frailty status assessed by the clinical frailty scale (CFS) to the SOFA score (SOFA-CFS) improves the performance of the SOFA score alone in predicting the hospital mortality of elderly critically ill patients. METHODS: A prospective observational study performed between February 2015 and February 2016 including 189 patients aged ≥65 years and hospitalized ≥24 h in the intensive care unit (ICU). RESULTS: The SOFA-CFS score did not improve the performance of the SOFA score alone in predicting hospital mortality (AUC = 0.66, 95% CI 0.58-0.74 vs AUC = 0.63, 95% CI 0.55-0.72, respectively, p = 0.082). The AUC of the CFS score was 0.62 (95% CI 0.53-0.71). In the multivariable analysis, age (OR: 1.09, 95% CI 1.03-1.16, p = 0.006), McCabe score C vs A (reference) and B vs A (reference) (OR: 8.28, 95% CI 2.83-24.27and OR: 2.29, 95% CI 1.02-5.12, p = 0.006, respectively), Glasgow coma score at admission (OR: 0.31, 95% CI 0.14-0.48, p = 0.003), and SOFA score (OR: 1.11, 95% CI 1.01-1.23, p = 0.037) were risk factors for hospital mortality. CONCLUSIONS: The performance of the SOFA score in predicting hospital mortality was low, although it was an independent risk factor for mortality. The combination of frailty status with the SOFA score did not improve the performance of the SOFA score alone.
PURPOSE: To determine whether the addition of the frailty status assessed by the clinical frailty scale (CFS) to the SOFA score (SOFA-CFS) improves the performance of the SOFA score alone in predicting the hospital mortality of elderly critically ill patients. METHODS: A prospective observational study performed between February 2015 and February 2016 including 189 patients aged ≥65 years and hospitalized ≥24 h in the intensive care unit (ICU). RESULTS: The SOFA-CFS score did not improve the performance of the SOFA score alone in predicting hospital mortality (AUC = 0.66, 95% CI 0.58-0.74 vs AUC = 0.63, 95% CI 0.55-0.72, respectively, p = 0.082). The AUC of the CFS score was 0.62 (95% CI 0.53-0.71). In the multivariable analysis, age (OR: 1.09, 95% CI 1.03-1.16, p = 0.006), McCabe score C vs A (reference) and B vs A (reference) (OR: 8.28, 95% CI 2.83-24.27and OR: 2.29, 95% CI 1.02-5.12, p = 0.006, respectively), Glasgow coma score at admission (OR: 0.31, 95% CI 0.14-0.48, p = 0.003), and SOFA score (OR: 1.11, 95% CI 1.01-1.23, p = 0.037) were risk factors for hospital mortality. CONCLUSIONS: The performance of the SOFA score in predicting hospital mortality was low, although it was an independent risk factor for mortality. The combination of frailty status with the SOFA score did not improve the performance of the SOFA score alone.
Authors: Fernando G Zampieri; Theodore J Iwashyna; Elizabeth M Viglianti; Leandro U Taniguchi; William N Viana; Roberto Costa; Thiago D Corrêa; Carlos Eduardo N Moreira; Marcelo O Maia; Giulliana M Moralez; Thiago Lisboa; Marcus A Ferez; Carlos Eduardo F Freitas; Clayton B de Carvalho; Bruno F Mazza; Mariza F A Lima; Grazielle V Ramos; Aline R Silva; Fernando A Bozza; Jorge I F Salluh; Marcio Soares Journal: Intensive Care Med Date: 2018-08-13 Impact factor: 17.440
Authors: Raúl López-Izquierdo; Pablo Del Brio-Ibañez; Francisco Martín-Rodríguez; Alicia Mohedano-Moriano; Begoña Polonio-López; Clara Maestre-Miquel; Antonio Viñuela; Carlos Durantez-Fernández; Miguel Á Castro Villamor; José L Martín-Conty Journal: Int J Environ Res Public Health Date: 2020-11-12 Impact factor: 3.390